Polimorfismo del gen de la tiopurina S-metiltransferasa en donantes de sangre de un hospital universitario
Background: Thiopurine S-methyltransferase (TPMT) is a cytosolic enzyme that catalyzes the S-methylation of 6-mercaptopurine and azathioprine. Low-activity phenotypes are correlated with polymorphism in the TPMT gene. Patients with low or undetectable TMPT activity could develop severe myelosuppress...
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| Auteurs principaux: | , , , , , |
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| Langue: | Spanish / Castilian |
| Publié: |
Sociedad Médica de Santiago
2009
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| Accès en ligne: | http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009000200001 |
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