Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile

Background: The homeostasis assessment model for insulin resistance (HOMA-IR) estimates insulin resistance using basal insulin and glucose values and has a good concordance with values obtained with the euglycemic clamp. However it has a high variability that depends on environmental, genetic and ph...

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Autores principales:	Garmendia,María Luisa, Lera,Lydia, Sánchez,Hugo, Uauy,Ricardo, Albala,Cecilia
Lenguaje:	Spanish / Castilian
Publicado:	Sociedad Médica de Santiago 2009
Materias:	Aged Diabetes mellitus Hyperinsulinism Insulin resistance
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100001
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spelling	oai:scielo:S0034-988720090011000012010-01-13Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de ChileGarmendia,María LuisaLera,LydiaSánchez,HugoUauy,RicardoAlbala,Cecilia Aged Diabetes mellitus Hyperinsulinism Insulin resistance Background: The homeostasis assessment model for insulin resistance (HOMA-IR) estimates insulin resistance using basal insulin and glucose values and has a good concordance with values obtained with the euglycemic clamp. However it has a high variability that depends on environmental, genetic and physiologic factors. Therefore it is imperative to establish normal HOMA values in different populations. Aim: To report HOMA-IR values in Chilean elderly subjects and to determine the best cutoff point to diagnose insulin resistance. Material and methods: Cross sectional study of 1003 subjects older than 60 years of whom 803 (71% women) did not have diabetes. In 154 subjects, an oral glucose tolerance test was also performed. Insulin resistance (IR) was defined as the HOMA value corresponding to percentile 75 of subjects without over or underweight. The behavior of HOMA-IR in metabolic syndrome was studied and receiver operating curves (ROC) were calculated, using glucose intolerance defined as a blood glucose over 140 mg/dl and hyperinsulinemia, defined as a serum insulin over 60 µU/ml, two hours after the glucose load. Results: Median HOMA-IR values were 1.7. Percentile 75 in subjects without obesity or underweight was 2.57. The area under the ROC curve, when comparing HOMA-IR with glucose intolerance and hyperinsulinemia, was 0.8 (95% confidence values 0.72-0.87), with HOMA-IR values ranging from 2.04 to 2.33. Conclusions: HOMA-IR is a useful method to determine insulin resistance in epidemiological studies. The HOMA-IR cutoff point for insulin resistance defined in thi spopulation was 2.6.info:eu-repo/semantics/openAccessSociedad Médica de SantiagoRevista médica de Chile v.137 n.11 20092009-11-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100001es10.4067/S0034-98872009001100001
institution	Scielo Chile
collection	Scielo Chile
language	Spanish / Castilian
topic	Aged Diabetes mellitus Hyperinsulinism Insulin resistance
spellingShingle	Aged Diabetes mellitus Hyperinsulinism Insulin resistance Garmendia,María Luisa Lera,Lydia Sánchez,Hugo Uauy,Ricardo Albala,Cecilia Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
description	Background: The homeostasis assessment model for insulin resistance (HOMA-IR) estimates insulin resistance using basal insulin and glucose values and has a good concordance with values obtained with the euglycemic clamp. However it has a high variability that depends on environmental, genetic and physiologic factors. Therefore it is imperative to establish normal HOMA values in different populations. Aim: To report HOMA-IR values in Chilean elderly subjects and to determine the best cutoff point to diagnose insulin resistance. Material and methods: Cross sectional study of 1003 subjects older than 60 years of whom 803 (71% women) did not have diabetes. In 154 subjects, an oral glucose tolerance test was also performed. Insulin resistance (IR) was defined as the HOMA value corresponding to percentile 75 of subjects without over or underweight. The behavior of HOMA-IR in metabolic syndrome was studied and receiver operating curves (ROC) were calculated, using glucose intolerance defined as a blood glucose over 140 mg/dl and hyperinsulinemia, defined as a serum insulin over 60 µU/ml, two hours after the glucose load. Results: Median HOMA-IR values were 1.7. Percentile 75 in subjects without obesity or underweight was 2.57. The area under the ROC curve, when comparing HOMA-IR with glucose intolerance and hyperinsulinemia, was 0.8 (95% confidence values 0.72-0.87), with HOMA-IR values ranging from 2.04 to 2.33. Conclusions: HOMA-IR is a useful method to determine insulin resistance in epidemiological studies. The HOMA-IR cutoff point for insulin resistance defined in thi spopulation was 2.6.
author	Garmendia,María Luisa Lera,Lydia Sánchez,Hugo Uauy,Ricardo Albala,Cecilia
author_facet	Garmendia,María Luisa Lera,Lydia Sánchez,Hugo Uauy,Ricardo Albala,Cecilia
author_sort	Garmendia,María Luisa
title	Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
title_short	Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
title_full	Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
title_fullStr	Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
title_full_unstemmed	Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile
title_sort	valores normativos de resistencia a la insulina mediante homa-ir en adultos mayores de santiago de chile
publisher	Sociedad Médica de Santiago
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0034-98872009001100001
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Valores normativos de resistencia a la insulina mediante HOMA-IR en adultos mayores de Santiago de Chile

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