Zinc in the prevention of Fe2initiated lipid and protein oxidation

In the present study we characterized the capacity of zinc to protect lipids and proteins from Fe2+-initiated oxidative damage. The effects of zinc on lipid oxidation were investigated in liposomes composed of brain phosphatidylcholine (PC) and phosphatidylserine (PS) at a molar relationship of 60:4...

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Autores principales:	ZAGO,M. PAOLA, VERSTRAETEN,SANDRA V., OTEIZA,PATRICIA I.
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2000
Materias:	aluminum catechins free radicals iron lipid peroxidation zinc
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200014
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spelling	oai:scielo:S0716-976020000002000142010-02-11Zinc in the prevention of Fe2initiated lipid and protein oxidationZAGO,M. PAOLAVERSTRAETEN,SANDRA V.OTEIZA,PATRICIA I. aluminum catechins free radicals iron lipid peroxidation zinc In the present study we characterized the capacity of zinc to protect lipids and proteins from Fe2+-initiated oxidative damage. The effects of zinc on lipid oxidation were investigated in liposomes composed of brain phosphatidylcholine (PC) and phosphatidylserine (PS) at a molar relationship of 60:40 (PC:PS, 60:40). Lipid oxidation was evaluated as the oxidation of cis-parinaric acid or as the formation of 2-thiobarbituric acid-reactive substances (TBARS). Zinc protected liposomes from Fe2+ (2.5-50 muM)-supported lipid oxidation. However, zinc (50 muM) did not prevent the oxidative inactivation of glutamine synthelase and glucose 6-phosphate dehydrogenase when rat brain superntants were oxidized in the presence of 5 muM Fe2+ and 0.5 mM H2O2 .We also studied the interactions of zinc with epicatechin in the prevention of liid oxidation in liposomes. The simulaneous addition of 0.5 muM epicatechin (EC) and 50 muM zinc or EC separately. Zinc (50 muM) also protecte liposomes from the stimulatory effect of aluminum on Fe2+-initiated lipid oxidation. Zinc could play an important role as an antioxidant in biological systems, replacing iron and other metals with pro-oxidant activity from binding sites and interacting with other components of the oxidant defense system.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.33 n.2 20002000-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200014en10.4067/S0716-97602000000200014
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	aluminum catechins free radicals iron lipid peroxidation zinc
spellingShingle	aluminum catechins free radicals iron lipid peroxidation zinc ZAGO,M. PAOLA VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I. Zinc in the prevention of Fe2initiated lipid and protein oxidation
description	In the present study we characterized the capacity of zinc to protect lipids and proteins from Fe2+-initiated oxidative damage. The effects of zinc on lipid oxidation were investigated in liposomes composed of brain phosphatidylcholine (PC) and phosphatidylserine (PS) at a molar relationship of 60:40 (PC:PS, 60:40). Lipid oxidation was evaluated as the oxidation of cis-parinaric acid or as the formation of 2-thiobarbituric acid-reactive substances (TBARS). Zinc protected liposomes from Fe2+ (2.5-50 muM)-supported lipid oxidation. However, zinc (50 muM) did not prevent the oxidative inactivation of glutamine synthelase and glucose 6-phosphate dehydrogenase when rat brain superntants were oxidized in the presence of 5 muM Fe2+ and 0.5 mM H2O2 .We also studied the interactions of zinc with epicatechin in the prevention of liid oxidation in liposomes. The simulaneous addition of 0.5 muM epicatechin (EC) and 50 muM zinc or EC separately. Zinc (50 muM) also protecte liposomes from the stimulatory effect of aluminum on Fe2+-initiated lipid oxidation. Zinc could play an important role as an antioxidant in biological systems, replacing iron and other metals with pro-oxidant activity from binding sites and interacting with other components of the oxidant defense system.
author	ZAGO,M. PAOLA VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I.
author_facet	ZAGO,M. PAOLA VERSTRAETEN,SANDRA V. OTEIZA,PATRICIA I.
author_sort	ZAGO,M. PAOLA
title	Zinc in the prevention of Fe2initiated lipid and protein oxidation
title_short	Zinc in the prevention of Fe2initiated lipid and protein oxidation
title_full	Zinc in the prevention of Fe2initiated lipid and protein oxidation
title_fullStr	Zinc in the prevention of Fe2initiated lipid and protein oxidation
title_full_unstemmed	Zinc in the prevention of Fe2initiated lipid and protein oxidation
title_sort	zinc in the prevention of fe2initiated lipid and protein oxidation
publisher	Sociedad de Biología de Chile
publishDate	2000
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602000000200014
work_keys_str_mv	AT zagompaola zincinthepreventionoffe2initiatedlipidandproteinoxidation AT verstraetensandrav zincinthepreventionoffe2initiatedlipidandproteinoxidation AT oteizapatriciai zincinthepreventionoffe2initiatedlipidandproteinoxidation
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Zinc in the prevention of Fe2initiated lipid and protein oxidation

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