Local regulation of the axonal phenotype, a case of merotrophism

In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' sta...

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Autores principales:	COURT,FELIPE A, ÁLVAREZ,JAIME
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2005
Materias:	axon protein synthesis nerve regeneration Schwann cell Wld s
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009
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spelling	oai:scielo:S0716-976020050004000092006-04-18Local regulation of the axonal phenotype, a case of merotrophismCOURT,FELIPE AÁLVAREZ,JAIME axon protein synthesis nerve regeneration Schwann cell Wld s In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.4 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009en10.4067/S0716-97602005000400009
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	axon protein synthesis nerve regeneration Schwann cell Wld s
spellingShingle	axon protein synthesis nerve regeneration Schwann cell Wld s COURT,FELIPE A ÁLVAREZ,JAIME Local regulation of the axonal phenotype, a case of merotrophism
description	In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.
author	COURT,FELIPE A ÁLVAREZ,JAIME
author_facet	COURT,FELIPE A ÁLVAREZ,JAIME
author_sort	COURT,FELIPE A
title	Local regulation of the axonal phenotype, a case of merotrophism
title_short	Local regulation of the axonal phenotype, a case of merotrophism
title_full	Local regulation of the axonal phenotype, a case of merotrophism
title_fullStr	Local regulation of the axonal phenotype, a case of merotrophism
title_full_unstemmed	Local regulation of the axonal phenotype, a case of merotrophism
title_sort	local regulation of the axonal phenotype, a case of merotrophism
publisher	Sociedad de Biología de Chile
publishDate	2005
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009
work_keys_str_mv	AT courtfelipea localregulationoftheaxonalphenotypeacaseofmerotrophism AT alvarezjaime localregulationoftheaxonalphenotypeacaseofmerotrophism
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Local regulation of the axonal phenotype, a case of merotrophism

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