Local regulation of the axonal phenotype, a case of merotrophism

Local regulation of the axonal phenotype, a case of merotrophism

In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' sta...

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Auteurs principaux: COURT,FELIPE A, ÁLVAREZ,JAIME
Langue:English
Publié: Sociedad de Biología de Chile 2005
Sujets:
axon
protein synthesis
nerve regeneration
Schwann cell
Wld s
Accès en ligne:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009
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spelling oai:scielo:S0716-976020050004000092006-04-18Local regulation of the axonal phenotype, a case of merotrophismCOURT,FELIPE AÁLVAREZ,JAIME axon protein synthesis nerve regeneration Schwann cell Wld s In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.info:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.38 n.4 20052005-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009en10.4067/S0716-97602005000400009
institution Scielo Chile
collection Scielo Chile
language English
topic axon
protein synthesis
nerve regeneration
Schwann cell
Wld s
spellingShingle axon
protein synthesis
nerve regeneration
Schwann cell
Wld s
COURT,FELIPE A
ÁLVAREZ,JAIME
Local regulation of the axonal phenotype, a case of merotrophism
description In this essay, we show that several anatomical features of the axon, namely, microtubular content, caliber and extension of sprouts, correlate on a local basis with the particular condition of the glial cell, i.e., the anatomy of axons is dynamic, although it is seen usually in its `normal' state. The occurrence of ribosomes and messenger RNAs in the axon suggests that axoplasmic proteins are most likely synthesized locally, at variance with the accepted notion that they are supplied by the cell body. We propose that the supporting cell (oligodendrocyte or Schwann cell) regulates the axonal phenotype by fine-tuning the ongoing axonal protein synthesis.
author COURT,FELIPE A
ÁLVAREZ,JAIME
author_facet COURT,FELIPE A
ÁLVAREZ,JAIME
author_sort COURT,FELIPE A
title Local regulation of the axonal phenotype, a case of merotrophism
title_short Local regulation of the axonal phenotype, a case of merotrophism
title_full Local regulation of the axonal phenotype, a case of merotrophism
title_fullStr Local regulation of the axonal phenotype, a case of merotrophism
title_full_unstemmed Local regulation of the axonal phenotype, a case of merotrophism
title_sort local regulation of the axonal phenotype, a case of merotrophism
publisher Sociedad de Biología de Chile
publishDate 2005
url http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400009
work_keys_str_mv AT courtfelipea localregulationoftheaxonalphenotypeacaseofmerotrophism
AT alvarezjaime localregulationoftheaxonalphenotypeacaseofmerotrophism
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