The functional links between prion protein and copper

Prion diseases are fatal neurodegenerative disorders associated with the conversion of the cellular prion protein (PrPC) into a pathologic isoform. Although the physiological function of PrPC remains unknown, evidence relates PrPC to copper metabolism and oxidative stress as suggested by its copper-...

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Autores principales: VARELA-NALLAR,LORENA, TOLEDO,ENRIQUE M, CHACÓN,MARCELO A, INESTROSA,NIBALDO C
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2006
Materias:
MRE
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100005
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