Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets

Protein kinase C isoform specificity of cholinergic potentiation of glucose-induced pulsatile 5-HT/ insulin release from mouse pancreatic islets

Thymeleatoxin (TMX), an activator of Ca2+-sensitive protein kinase C (cPKC) isoforms, was used to assess the PKC isoform specificity of cholinergic potentiation of glucose (11 mM)-induced pulsatile 5-HT/insulin release (PIR) from single mouse pancreatic islets. TMX (100 nM) and carbachol (Cch, 50 mM...

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Autores principales: BALDEIRAS,INÊS E, SANTOS,ROSA M, ROSÁRIO,LUÍS M
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2006
Materias:
Cytosolic free Ca2+ concentration
5-HT amperometry
islet of Langerhans
protein kinase C
pulsatile insulin release
thymeleatoxin
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300014
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000300014

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