Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the aut...

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Autores principales:	LÓPEZ-ALARCÓN,CAMILO, SPEISKY,HERNÁN, LISSI,EDUARDO
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2007
Materias:	5-Aminosalicylic acid Antioxidant LDL oxidation
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006
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spelling	oai:scielo:S0716-976020070002000062008-06-13Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidationLÓPEZ-ALARCÓN,CAMILOSPEISKY,HERNÁNLISSI,EDUARDO 5-Aminosalicylic acid Antioxidant LDL oxidation The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacityinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.40 n.2 20072007-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006en10.4067/S0716-97602007000200006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	5-Aminosalicylic acid Antioxidant LDL oxidation
spellingShingle	5-Aminosalicylic acid Antioxidant LDL oxidation LÓPEZ-ALARCÓN,CAMILO SPEISKY,HERNÁN LISSI,EDUARDO Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
description	The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity
author	LÓPEZ-ALARCÓN,CAMILO SPEISKY,HERNÁN LISSI,EDUARDO
author_facet	LÓPEZ-ALARCÓN,CAMILO SPEISKY,HERNÁN LISSI,EDUARDO
author_sort	LÓPEZ-ALARCÓN,CAMILO
title	Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
title_short	Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
title_full	Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
title_fullStr	Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
title_full_unstemmed	Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation
title_sort	antioxidant effect of 5-amino salicylic acid on copper-mediated ldl oxidation
publisher	Sociedad de Biología de Chile
publishDate	2007
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006
work_keys_str_mv	AT lopezalarconcamilo antioxidanteffectof5aminosalicylicacidoncoppermediatedldloxidation AT speiskyhernan antioxidanteffectof5aminosalicylicacidoncoppermediatedldloxidation AT lissieduardo antioxidanteffectof5aminosalicylicacidoncoppermediatedldloxidation
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Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation

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