Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human p...

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Main Authors: GALARCE,GLORIA D, FONCEA,ROCÍO E, EDWARDS,ANA M, PESSOA-MAHANA,HERNÁN, PESSOA-MAHANA,CARLOS D, EBENSPERGER,ROBERTO A
Language:English
Published: Sociedad de Biología de Chile 2008
Subjects:
anti-inflammatory agents
benzimidazoquinazoline derivatives
TNF-á inhibitors
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006

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