Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human p...

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Autores principales:	GALARCE,GLORIA D, FONCEA,ROCÍO E, EDWARDS,ANA M, PESSOA-MAHANA,HERNÁN, PESSOA-MAHANA,CARLOS D, EBENSPERGER,ROBERTO A
Lenguaje:	English
Publicado:	Sociedad de Biología de Chile 2008
Materias:	anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
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spelling	oai:scielo:S0716-976020080001000062008-08-21Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretionGALARCE,GLORIA DFONCEA,ROCÍO EEDWARDS,ANA MPESSOA-MAHANA,HERNÁNPESSOA-MAHANA,CARLOS DEBENSPERGER,ROBERTO A anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agentsinfo:eu-repo/semantics/openAccessSociedad de Biología de ChileBiological Research v.41 n.1 20082008-01-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006en10.4067/S0716-97602008000100006
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors
spellingShingle	anti-inflammatory agents benzimidazoquinazoline derivatives TNF-á inhibitors GALARCE,GLORIA D FONCEA,ROCÍO E EDWARDS,ANA M PESSOA-MAHANA,HERNÁN PESSOA-MAHANA,CARLOS D EBENSPERGER,ROBERTO A Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
description	This study describes the effect of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as tumor necrosis factor alpha (TNF-á) production inhibitors. The newly synthesized compounds were tested for their in vitro ability to inhibit the lipolysaccharide (LPS) induced TNF-á secretion in the human promyelocytic cell line HL-60. The compound 6-Phenyl-benzimidazo [1,2-c] quinazoline, coded as Gl, resulted as the most potent inhibitor and with no significant cytotoxic activity. Thus, 6-Arylbenzimidazo [1,2-c] quinazoline derivatives may have a potential as anti-inflammatory agents
author	GALARCE,GLORIA D FONCEA,ROCÍO E EDWARDS,ANA M PESSOA-MAHANA,HERNÁN PESSOA-MAHANA,CARLOS D EBENSPERGER,ROBERTO A
author_facet	GALARCE,GLORIA D FONCEA,ROCÍO E EDWARDS,ANA M PESSOA-MAHANA,HERNÁN PESSOA-MAHANA,CARLOS D EBENSPERGER,ROBERTO A
author_sort	GALARCE,GLORIA D
title	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_short	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_full	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_fullStr	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_full_unstemmed	Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion
title_sort	biological evaluation of novel 6-arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of lps-induced tnf- alpha secretion
publisher	Sociedad de Biología de Chile
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100006
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Biological evaluation of novel 6-Arylbenzimidazo [1,2-c] quinazoline derivatives as inhibitors of LPS-induced TNF- alpha secretion

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