Donepezil reverses buprenorphine-induced central respiratory depression in anesthetized rabbits

Buprenorphine is a mixed opioid receptor agonist-antagonist used in acute and chronic pain management. Although this agent's analgesic effect increases in a dose-dependent manner, buprenorphine-induced respiratory depression shows a marked ceiling effect at higher doses, which is considered to...

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Bibliographic Details
Main Authors: SAKURABA,SHIGEKI, TSUJITA,MIKI, ARISAKA,HIROFUMI, TAKEDA,JUNZO, YOSHIDA,KAZUICHI, KUWANA,SHUN-ICHI
Language:English
Published: Sociedad de Biología de Chile 2009
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Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000400008
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