Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Mutations in BRCA1, BRCA2 and other breast and ovarian cancer susceptibility genes in Central and South American populations

Abstract Breast cancer (BC) is the most common malignancy among women worldwide. A major advance in the understanding of the genetic etiology of BC was the discovery of BRCA1 and BRCA2 (BRCA1/2) genes, which are considered high-penetrance BC genes. In non-carriers of BRCA1/2 mutations, disease susce...

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Autores principales: Jara,Lilian, Morales,Sebastian, Mayo,Tomas de, Gonzalez–Hormazabal,Patricio, Carrasco,Valentina, Godoy,Raul
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2017
Materias:
Hereditary and early onset breast cancer
Susceptibility genes
Pathogenic point mutations
Large genomic rearrangements
Ethnic composition
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100505
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