Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

Downregulation of TGF-β1 suppressed proliferation and increased chemosensitivity of ovarian cancer cells by promoting BRCA1/Smad3 signaling

Abstract Background: Studies have demonstrated that transforming growth factor beta-1 (TGF-β1) exhibits oncogenic activity in different types of cancer, including ovarian cancer (OC). However, its regulatory mechanism in OC and whether TGF-β1 is involved in chemosensitivity regula...

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Bibliographic Details
Main Authors: Wang,Yanqiu, Xiang,Jun, Wang,Jianjun, Ji,Yazhong
Language:English
Published: Sociedad de Biología de Chile 2018
Subjects:
Ovarian cancer
TGF-β1
BRCA1
Smad3
Proliferation
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100248
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602018000100248

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