Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell lines

Functional and transcriptomic characterization of carboplatin-resistant A2780 ovarian cancer cell lines

Abstract Background: Ovarian cancer is a significant cancer-related cause of death in women worldwide. The most used chemotherapeutic regimen is based on carboplatin (CBDCA). However, CBDCA resistance is the main obstacle to a better prognosis. An in vitro drug-resistant cell model would help in th...

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Main Authors: Viscarra,Tamara, Buchegger,Kurt, Jofre,Ignacio, Riquelme,Ismael, Zanella,Louise, Abanto,Michel, Parker,Alyssa C., Piccolo,Stephen R., Roa,Juan Carlos, Ili,Carmen, Brebi,Priscilla
Language:English
Published: Sociedad de Biología de Chile 2019
Subjects:
A2780 cell line
Carboplatin
Drug resistance
Wnt/β-catenin-signaling pathway
Integrin signaling pathway
Ovarian cancer
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100211
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