Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Palmitic acid-induced lipotoxicity promotes a novel interplay between Akt-mTOR, IRS-1, and FFAR1 signaling in pancreatic β-cells

Abstract Background: Free fatty acid receptor 1 (FFAR1) is G-protein coupled receptor predominantly expressed in pancreatic β-cells that is activated by a variety of free fatty acids (FFAs). Once activated, it promotes glucose-stimulated insulin secretion (GSIS). However, increased levels...

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Autores principales: Marafie,Sulaiman K., Al-Shawaf,Eman M., Abubaker,Jehad, Arefanian,Hossein
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2019
Materias:
Palmitic acid
Lipotoxicity
Insulin resistance
Type 2 diabetes
FFAR1
mTOR
Akt
IRS-1
INSR
β-cells
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100241
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100241

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