Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Neuroprotective effects of an Nrf2 agonist on high glucose-induced damage in HT22 cells

Abstract Background: Oxidative stress is the hallmark of diabetic encephalopathy, which may be caused by hyperglycaemic toxicity. We aimed to discover pharmacologic targets to restore redox homeostasis. We identified the transcription factor Nrf2 as such a target. Methods: HT22 cells were cultured...

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Autores principales: Zhao,Jiangpei, Liu,Lerong, Li,Xia, Zhang,Lingxiao, Lv,Jing, Guo,Xueli, Chen,Hui, Zhao,Tongfeng
Lenguaje:English
Publicado: Sociedad de Biología de Chile 2019
Materias:
Sulforaphane
High glucose
Hippocampus
NF-E2-related factor 2
Nuclear factor-κΒ
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602019000100249
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