Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Mast cells-derived MiR-223 destroys intestinal barrier function by inhibition of CLDN8 expression in intestinal epithelial cells

Abstract Background: Mast cells (MCs) have been found to play a critical role during development of inflammatory bowel disease (IBD) that characterized by dysregulation of inflammation and impaired intestinal barrier function. However, the function of MCs in IBD remains to be fully elucidated. Res...

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Main Authors: Li,Musheng, Zhao,Junhong, Cao,Meiwan, Liu,Ruitao, Chen,Guanhua, Li,Songyu, Xie,Yuanwen, Xie,Jing, Cheng,Yang, Huang,Ling, Su,Mingmin, Xu,Yuxin, Zheng,Mingyue, Zou,Kejian, Geng,Lanlan, Xu,Wanfu, Gong,Sitang
Language:English
Published: Sociedad de Biología de Chile 2020
Subjects:
Mast cells
Exosomes
miR-223
Claudin 8
Inflammatory bowel disease
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602020000100210
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