Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Testosterone activates glucose metabolism through AMPK and androgen signaling in cardiomyocyte hypertrophy

Abstract Background: Testosterone regulates nutrient and energy balance to maintain protein synthesis and metabolism in cardiomyocytes, but supraphysiological concentrations induce cardiac hypertrophy. Previously, we determined that testosterone increased glucose uptake—via AMP-activated...

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Main Authors: Troncoso,Mayarling Francisca, Pavez,Mario, Wilson,Carlos, Lagos,Daniel, Duran,Javier, Ramos,Sebastián, Barrientos,Genaro, Silva,Patricio, Llanos,Paola, Basualto-Alarcón,Carla, Westenbrink,B. Daan, Lavandero,Sergio, Estrada,Manuel
Language:English
Published: Sociedad de Biología de Chile 2021
Subjects:
Testosterone
AMP-activated protein kinase
Glucose transport
Glycolysis
Androgen receptor
Cardiac hypertrophy
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602021000100203
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