Rapid automated selection of mammalian cell line secreting high level of humanized monoclonal antibody using Clone Pix FL system and the correlation between exterior median intensity and antibody productivity

The selection of high-producing mammalian cell lines is a crucial step in process development for the production of biopharmaceuticals. Previously, cloning by limiting dilution method was used to isolate monoclonal NS0 cells secreting high levels of humanized-C2 monoclonal antibodies. However limiti...

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Auteurs principaux: Dharshanan,Suba, Chong,Heilly, Hung,Cheah Swee, Zamrod,Zulkeflie, Kamal,Nazlee
Langue:English
Publié: Pontificia Universidad Católica de Valparaíso 2011
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Accès en ligne:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000200008
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