Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells

Rapamycin pre-treatment abrogates Tumour Necrosis Factor-α down-regulatory effects on LXR-α and PXR mRNA expression via inhibition of c-Jun N-terminal kinase 1 activation in HepG2 cells

The Liver X Receptor (LXR) and Pregnane X Receptor (PXR) are members of the nuclear receptor superfamily. Previously, they have been classified as important regulators of lipid homeostasis. However, recent studies have shown that they may be implicated in anti-inflammatory responses as well. This st...

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Main Authors: Ng,Di-Lin, Tie,Shin-Wei, Ong,Pei-Chin, Lim,Wyi-Sian, Tengku-Muhammad,Tengku-Sifzizul, Choo,Quok-Cheong, Chew,Choy-Hoong
Language:English
Published: Pontificia Universidad Católica de Valparaíso 2011
Subjects:
Akt
c-Jun
homeostasis
inflammation
MKK7
transcription factor
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582011000300008
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