Expression and purification of soluble single-chain Fv against human fibroblast growth factor receptor 3 fused with Sumo tag in Escherichia coli

Expression and purification of soluble single-chain Fv against human fibroblast growth factor receptor 3 fused with Sumo tag in Escherichia coli

Background Overexpression or mutated activation of Fibroblast growth factor receptor 3 (FGFR3) is involved in the pathogenesis of many tumors. More and more studies focus on the potential usage of therapeutic antibodies against FGFR3. Results In this study, a novel single-chain Fv (ScFv) against FGF...

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Main Authors: Liu,Zixuan, Zhang,Jizhou, Fan,Hongqiong, Yin,Ruofeng, Zheng,Zhong, Xu,Qian, Liu,Qing, He,Haiting, Peng,Xiaofan, Wang,XinXin, Li,Xiaokun, Xiao,Yechen
Language:English
Published: Pontificia Universidad Católica de Valparaíso 2015
Subjects:
Escherichia coli
Fibroblast growth factor receptor 3
Single-chain Fv antibody
Soluble expression
Sumo tag
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-34582015000400008
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