Early Administration of Peroxisomicine A1 (T-514 Extracted from K. parvifolia Seeds) Causes Necrosis of Implanted TC-1 Cells without Affecting Target Organs in a Murine Model

Early Administration of Peroxisomicine A1 (T-514 Extracted from K. parvifolia Seeds) Causes Necrosis of Implanted TC-1 Cells without Affecting Target Organs in a Murine Model

Peroxisomicine A1 (PA1), one of the toxins isolated from seeds of plants of the Karwinskia genus, whose targets organs are the liver, kidney, and lungs. There is a selective toxicity in vitro to cancer-cell lines derived from the lungs, liver, and colon, compared to normal cell lines. PA1 caused apo...

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Autores principales: Soto-Domínguez,Adolfo, Piñeyro-López,Alfredo, Saucedo-Cárdenas,Odila, Ramírez-Durónd,Rosalba, Waksman de Torres,Noemí, Sepúlveda-Saavedra,Julio
Lenguaje:English
Publicado: Sociedad Chilena de Anatomía 2012
Materias:
Antineoplasic effect
Necrosis
Peroxisomicine A1
Selective toxicity
TC-1 cells
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022012000100051
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