Metformin Pretreatment Ameliorates Diabetic Nephropathy Induced by a Combination of High Fat Diet and Streptozotocin in Rats

Metformin Pretreatment Ameliorates Diabetic Nephropathy Induced by a Combination of High Fat Diet and Streptozotocin in Rats

SUMMARY: Kidney injury secondary to diabetes is the most common cause of kidney failure. We sought to determine whether pretreatment with the insulin-sensitizing drug metformin prior to the induction of diabetes can protect the kidney against the development of diabetic nephropathy (DN) induced by a...

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Main Authors: Dallak,Mohammad, Bin-Jaliah,Ismaeel, Al-Hashem,Fahaid, Kamar,Samaa S, Kader,Dina H. Abdel, Amin,Shaimaa N, Haidara,Mohamed A, Al-Ani,Bahjat
Language:English
Published: Sociedad Chilena de Anatomía 2018
Subjects:
Diabetic nephropathy
Metformin
Inflammation
Rat model
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000300969
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