Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats

SUMMARY: Monosodium glutamate (MSG) is a flavor enhancer widely used in the food industry, with obesogenic properties, in addition to causing alterations in the oral cavity. The aim of the study was to observe the morphofunctional changes in the parotid gland after the administration of MSG in rats....

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Autores principales:	Roa,Ignacio, del Sol,Mariano
Lenguaje:	English
Publicado:	Sociedad Chilena de Anatomía 2020
Materias:	Monosodium glutamate Saliva Parotid gland Salivary flow pH α-amylase
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000401112
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spelling	oai:scielo:S0717-950220200004011122020-09-08Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley RatsRoa,Ignaciodel Sol,Mariano Monosodium glutamate Saliva Parotid gland Salivary flow pH α-amylase SUMMARY: Monosodium glutamate (MSG) is a flavor enhancer widely used in the food industry, with obesogenic properties, in addition to causing alterations in the oral cavity. The aim of the study was to observe the morphofunctional changes in the parotid gland after the administration of MSG in rats. 18 newborn male Sprague Dawley rats were used, divided into three groups (Control group; MSG1 group: 4 mg/g weight of monosodium glutamate, 5 doses, kept for 8 weeks, and MSG2 group: 4 mg/g weight of MSG, 5 doses, kept for 16 weeks). The body mass index (BMI) was calculated, and the salivary flow, pH, a-amylase activity, Na, Cl, K and Ca were analyzed by quantitative analysis. After euthanasia by ketamine/xylazine overdose, parotid volume was analyzed and stereology was performed. MSG administration caused an increase in BMI and a decrease in parotid volume as well as a reduction in salivary flow and pH and an increase in a-amylase activity, also increasing the salivary sodium and chlorine levels. Alterations in the normal stereological parameters of the gland were observed. Exposure to MSG caused morphofunctional alterations at parotid gland.info:eu-repo/semantics/openAccessSociedad Chilena de AnatomíaInternational Journal of Morphology v.38 n.4 20202020-08-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000401112en10.4067/S0717-95022020000401112
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Monosodium glutamate Saliva Parotid gland Salivary flow pH α-amylase
spellingShingle	Monosodium glutamate Saliva Parotid gland Salivary flow pH α-amylase Roa,Ignacio del Sol,Mariano Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
description	SUMMARY: Monosodium glutamate (MSG) is a flavor enhancer widely used in the food industry, with obesogenic properties, in addition to causing alterations in the oral cavity. The aim of the study was to observe the morphofunctional changes in the parotid gland after the administration of MSG in rats. 18 newborn male Sprague Dawley rats were used, divided into three groups (Control group; MSG1 group: 4 mg/g weight of monosodium glutamate, 5 doses, kept for 8 weeks, and MSG2 group: 4 mg/g weight of MSG, 5 doses, kept for 16 weeks). The body mass index (BMI) was calculated, and the salivary flow, pH, a-amylase activity, Na, Cl, K and Ca were analyzed by quantitative analysis. After euthanasia by ketamine/xylazine overdose, parotid volume was analyzed and stereology was performed. MSG administration caused an increase in BMI and a decrease in parotid volume as well as a reduction in salivary flow and pH and an increase in a-amylase activity, also increasing the salivary sodium and chlorine levels. Alterations in the normal stereological parameters of the gland were observed. Exposure to MSG caused morphofunctional alterations at parotid gland.
author	Roa,Ignacio del Sol,Mariano
author_facet	Roa,Ignacio del Sol,Mariano
author_sort	Roa,Ignacio
title	Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
title_short	Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
title_full	Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
title_fullStr	Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
title_full_unstemmed	Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats
title_sort	monosodium glutamate alters the function and morphology of the parotid gland in sprague dawley rats
publisher	Sociedad Chilena de Anatomía
publishDate	2020
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022020000401112
work_keys_str_mv	AT roaignacio monosodiumglutamatealtersthefunctionandmorphologyoftheparotidglandinspraguedawleyrats AT delsolmariano monosodiumglutamatealtersthefunctionandmorphologyoftheparotidglandinspraguedawleyrats
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Monosodium Glutamate Alters the Function and Morphology of the Parotid Gland in Sprague Dawley Rats

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