Liver Structural Injury in Leptin-Deficient (ob/ob) Mice: Lipogenesis, Fibrogenesis, Inflammation, and Apoptosis

Liver Structural Injury in Leptin-Deficient (ob/ob) Mice: Lipogenesis, Fibrogenesis, Inflammation, and Apoptosis

SUMMARY: Nonalcoholic fatty liver disease (NAFLD) might progress the steatosis to nonalcoholic steatohepatitis (NASH), reaching a cirrhosis state and possibly hepatocellular carcinoma. The liver of three-month-old C57BL/6J mice (wild-type, WT group, n=10) and leptin- deficient obese mice (ob/ob grou...

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Bibliographic Details
Main Authors: Martins,Fabiane Ferreira, Souza-Mello,Vanessa, Carvalho,Jorge Jose de, del Sol,Mariano, Aguila,Marcia Barbosa, Mandarim-de-Lacerda,Carlos Alberto
Language:English
Published: Sociedad Chilena de Anatomía 2021
Subjects:
Steatosis
Stellate cell
Fibrosis
Confocal microscopy
Stereology
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022021000300732
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