ASSESSMENT OF THE HYDROLYTIC DEGRADATION OF LOVASTATIN BY HPLC

In this work an HPLC stability-indicating method was developed and applied to study the hydrolytic behaviour of lovastatin in different simulated fluids. The selected chromatographic conditions were a C-18 column, acetonitrile/methanol/phosphate buffer solution pH 4 (32/33/35) as mobile phase, 45ºC...

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Autores principales: ÁLVAREZ-LUEJE,A, PASTINE,J, SQUELLA,J.A, NUÑEZ-VERGARA,L.J
Lenguaje:English
Publicado: Sociedad Chilena de Química 2005
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Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072005000400002
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