DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION

A simple, sensitive and validated HPLC method has been developed to determine gemfibrozil and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a C-18 column using a mixture of 0.1 M ammonium acétate pH 5.0 and acetonitrile in the ratio of 15:85 (v/v) a...

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Autores principales:	ASHFAQ,MUHAMMAD, ULLAH KHAN,ISLAM, NADEEM ASGHAR,MUHAMMAD
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2008
Materias:	HPLC acetonitrile gemfibrozil simvastatin
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300015
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spelling	oai:scielo:S0717-970720080003000152008-10-23DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATIONASHFAQ,MUHAMMADULLAH KHAN,ISLAMNADEEM ASGHAR,MUHAMMAD HPLC acetonitrile gemfibrozil simvastatin A simple, sensitive and validated HPLC method has been developed to determine gemfibrozil and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a C-18 column using a mixture of 0.1 M ammonium acétate pH 5.0 and acetonitrile in the ratio of 15:85 (v/v) at a wavelength of 237 nm. Linearity of the method was found to be in the concentration range of 60-420 µg/ml forugemfibrozil and 1-7 µg/ml for simvastatin with correlation coefficient greater than 0.9999. The total eluting time for the two components is less than ten minutes. The method can be used for simultaneous determination of gemfibrozil and simvastatininfo:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.53 n.3 20082008-09-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300015en10.4067/S0717-97072008000300015
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	HPLC acetonitrile gemfibrozil simvastatin
spellingShingle	HPLC acetonitrile gemfibrozil simvastatin ASHFAQ,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ASGHAR,MUHAMMAD DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
description	A simple, sensitive and validated HPLC method has been developed to determine gemfibrozil and simvastatin simultaneously in synthetic mixture form. Chromatographic separation was achieved on a C-18 column using a mixture of 0.1 M ammonium acétate pH 5.0 and acetonitrile in the ratio of 15:85 (v/v) at a wavelength of 237 nm. Linearity of the method was found to be in the concentration range of 60-420 µg/ml forugemfibrozil and 1-7 µg/ml for simvastatin with correlation coefficient greater than 0.9999. The total eluting time for the two components is less than ten minutes. The method can be used for simultaneous determination of gemfibrozil and simvastatin
author	ASHFAQ,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ASGHAR,MUHAMMAD
author_facet	ASHFAQ,MUHAMMAD ULLAH KHAN,ISLAM NADEEM ASGHAR,MUHAMMAD
author_sort	ASHFAQ,MUHAMMAD
title	DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
title_short	DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
title_full	DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
title_fullStr	DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
title_full_unstemmed	DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION
title_sort	development and validation of liquid chromatographic method for gemfibrozil and simvastatin in binary combination
publisher	Sociedad Chilena de Química
publishDate	2008
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072008000300015
work_keys_str_mv	AT ashfaqmuhammad developmentandvalidationofliquidchromatographicmethodforgemfibrozilandsimvastatininbinarycombination AT ullahkhanislam developmentandvalidationofliquidchromatographicmethodforgemfibrozilandsimvastatininbinarycombination AT nadeemasgharmuhammad developmentandvalidationofliquidchromatographicmethodforgemfibrozilandsimvastatininbinarycombination
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DEVELOPMENT AND VALIDATION OF LIQUID CHROMATOGRAPHIC METHOD FOR GEMFIBROZIL AND SIMVASTATIN IN BINARY COMBINATION

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