SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY

SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY

New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substit...

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Autores principales: PESSOA-MAHANA,HERNÁN, GONZÁLEZ L,CHRISTIAN, ARAYA-MATURANA,RAMIRO, SAITZ B,CLAUDIO, PESSOA-MAHANA,C. DAVID
Lenguaje:English
Publicado: Sociedad Chilena de Química 2009
Materias:
Secotonine
arylpiperazines
5-HT1A binding affiniy
Acceso en línea:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200011
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200011

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