SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY

New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substit...

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Autores principales:	PESSOA-MAHANA,HERNÁN, GONZÁLEZ L,CHRISTIAN, ARAYA-MATURANA,RAMIRO, SAITZ B,CLAUDIO, PESSOA-MAHANA,C. DAVID
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	Secotonine arylpiperazines 5-HT1A binding affiniy
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200011
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spelling	oai:scielo:S0717-970720090002000112009-10-07SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITYPESSOA-MAHANA,HERNÁNGONZÁLEZ L,CHRISTIANARAYA-MATURANA,RAMIROSAITZ B,CLAUDIOPESSOA-MAHANA,C. DAVID Secotonine arylpiperazines 5-HT1A binding affiniy New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.2 20092009-06-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200011en10.4067/S0717-97072009000200011
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Secotonine arylpiperazines 5-HT1A binding affiniy
spellingShingle	Secotonine arylpiperazines 5-HT1A binding affiniy PESSOA-MAHANA,HERNÁN GONZÁLEZ L,CHRISTIAN ARAYA-MATURANA,RAMIRO SAITZ B,CLAUDIO PESSOA-MAHANA,C. DAVID SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
description	New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.
author	PESSOA-MAHANA,HERNÁN GONZÁLEZ L,CHRISTIAN ARAYA-MATURANA,RAMIRO SAITZ B,CLAUDIO PESSOA-MAHANA,C. DAVID
author_facet	PESSOA-MAHANA,HERNÁN GONZÁLEZ L,CHRISTIAN ARAYA-MATURANA,RAMIRO SAITZ B,CLAUDIO PESSOA-MAHANA,C. DAVID
author_sort	PESSOA-MAHANA,HERNÁN
title	SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
title_short	SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
title_full	SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
title_fullStr	SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
title_full_unstemmed	SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY
title_sort	synthesis of conformationally restricted n-{4-[4-(4,7-dimethoxy-benzo[b]thiophene-2-carbonyl)-1-piperazinyl]-phenyl}-arylcarboxamides potential ligands with 5-ht1a binding affinity
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000200011
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SYNTHESIS OF CONFORMATIONALLY RESTRICTED N-{4-[4-(4,7-DIMETHOXY-BENZO[b]THIOPHENE-2-CARBONYL)-1-PIPERAZINYL]-PHENYL}-ARYLCARBOXAMIDES POTENTIAL LIGANDS WITH 5-HT1A BINDING AFFINITY

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