IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS

In the present paper, we describe the in vitro availability of simvastatin, a potent HMG-CoA reductase inhibitor, in presence of losartan potassium, which is a non-peptide angiotensin II receptor antagonist. These studies were carried out at 37, 48 and 60°C in different pH environments simulating hu...

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Autores principales:	SAEED ARAYNE,M, SULTANA,NAJMA, HAROON,UROOJ, ZAIDI,BATOOL
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2009
Materias:	simvastatin losartan drug interactions charge-transfer complex
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400024
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spelling	oai:scielo:S0717-970720090004000242010-04-15IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONSSAEED ARAYNE,MSULTANA,NAJMAHAROON,UROOJZAIDI,BATOOL simvastatin losartan drug interactions charge-transfer complex In the present paper, we describe the in vitro availability of simvastatin, a potent HMG-CoA reductase inhibitor, in presence of losartan potassium, which is a non-peptide angiotensin II receptor antagonist. These studies were carried out at 37, 48 and 60°C in different pH environments simulating human body compartments. The reactions were studied by UV spectroscopy and the availability of both drugs in presence of each other was determined by deriving a simultaneous equation for two component system through modifcation of Beer`s law. The interactions were further characterized by IR and H¹NMR spectroscopic techniques. It was observed that availability of simvastatin in presence of losartan at 37 ºC in simulated gastric juice, at pH 7.4 and pH 9.0 was blocked by losartan through the formation of a charge-transfer complex while the availability of losartan in turn was immensely increased. In pH 4.0 these effects were reversed, availability of simvastatin increased and the availability of losartan was depressed. Similar results were observed at higher temperatures.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.54 n.4 20092009-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400024en10.4067/S0717-97072009000400024
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	simvastatin losartan drug interactions charge-transfer complex
spellingShingle	simvastatin losartan drug interactions charge-transfer complex SAEED ARAYNE,M SULTANA,NAJMA HAROON,UROOJ ZAIDI,BATOOL IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
description	In the present paper, we describe the in vitro availability of simvastatin, a potent HMG-CoA reductase inhibitor, in presence of losartan potassium, which is a non-peptide angiotensin II receptor antagonist. These studies were carried out at 37, 48 and 60°C in different pH environments simulating human body compartments. The reactions were studied by UV spectroscopy and the availability of both drugs in presence of each other was determined by deriving a simultaneous equation for two component system through modifcation of Beer`s law. The interactions were further characterized by IR and H¹NMR spectroscopic techniques. It was observed that availability of simvastatin in presence of losartan at 37 ºC in simulated gastric juice, at pH 7.4 and pH 9.0 was blocked by losartan through the formation of a charge-transfer complex while the availability of losartan in turn was immensely increased. In pH 4.0 these effects were reversed, availability of simvastatin increased and the availability of losartan was depressed. Similar results were observed at higher temperatures.
author	SAEED ARAYNE,M SULTANA,NAJMA HAROON,UROOJ ZAIDI,BATOOL
author_facet	SAEED ARAYNE,M SULTANA,NAJMA HAROON,UROOJ ZAIDI,BATOOL
author_sort	SAEED ARAYNE,M
title	IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
title_short	IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
title_full	IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
title_fullStr	IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
title_full_unstemmed	IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS
title_sort	in vitro evidences for simvastatin and losartan potassium interaction and its in vivo implications
publisher	Sociedad Chilena de Química
publishDate	2009
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072009000400024
work_keys_str_mv	AT saeedaraynem invitroevidencesforsimvastatinandlosartanpotassiuminteractionanditsinvivoimplications AT sultananajma invitroevidencesforsimvastatinandlosartanpotassiuminteractionanditsinvivoimplications AT haroonurooj invitroevidencesforsimvastatinandlosartanpotassiuminteractionanditsinvivoimplications AT zaidibatool invitroevidencesforsimvastatinandlosartanpotassiuminteractionanditsinvivoimplications
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IN VITRO EVIDENCES FOR SIMVASTATIN AND LOSARTAN POTASSIUM INTERACTION AND ITS IN VIVO IMPLICATIONS

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