STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS

Auranofin is a gold compound that is widely used for the treatment of rheumatoid arthritis. It is a monomeric linear complex with triethylphosphine and thiolate moieties bounded to an Au(I) center. Gold compounds are well known for their neurological and nephrotoxic implications. However, haematolog...

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Autores principales:	SUWALSKY,MARIO, GONZÁLEZ,RAQUEL, VILLENA,FERNANDO, BOLOGNIN,SILVIA
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2013
Materias:	Gold Au(I) phospholipid bilayer erythrocyte membrane neuroblastoma cells
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400021
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spelling	oai:scielo:S0717-970720130004000212014-09-02STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELSSUWALSKY,MARIOGONZÁLEZ,RAQUELVILLENA,FERNANDOBOLOGNIN,SILVIA Gold Au(I) phospholipid bilayer erythrocyte membrane neuroblastoma cells Auranofin is a gold compound that is widely used for the treatment of rheumatoid arthritis. It is a monomeric linear complex with triethylphosphine and thiolate moieties bounded to an Au(I) center. Gold compounds are well known for their neurological and nephrotoxic implications. However, haematological toxicity is one of the most serious toxic and less studied effects. The lack of information on these aspects of auranofin prompted us to study the structural effects induced on cell membranes, particularly that of human erythrocytes. Auranofin was incubated with intact erythrocytes and molecular models of the erythrocyte membrane. The latter consisted of multibilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), phospholipids classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. This report presents evidence in order that auranofin interacts with red cell membranes as follows: a) in scanning electron microscopy studies on human erythrocytes it was observed that auranofin induced shape changes; b) X-ray diffraction studies showed that auranofin induced increasing structural perturbation to DMPC and to a lower extent to DMPE bilayers. Additional experiments were performed in human neuroblastoma cells SH-SY5Y. A statistically significant decrease of cell viability was observed.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.58 n.4 20132013-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400021en10.4067/S0717-97072013000400021
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Gold Au(I) phospholipid bilayer erythrocyte membrane neuroblastoma cells
spellingShingle	Gold Au(I) phospholipid bilayer erythrocyte membrane neuroblastoma cells SUWALSKY,MARIO GONZÁLEZ,RAQUEL VILLENA,FERNANDO BOLOGNIN,SILVIA STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
description	Auranofin is a gold compound that is widely used for the treatment of rheumatoid arthritis. It is a monomeric linear complex with triethylphosphine and thiolate moieties bounded to an Au(I) center. Gold compounds are well known for their neurological and nephrotoxic implications. However, haematological toxicity is one of the most serious toxic and less studied effects. The lack of information on these aspects of auranofin prompted us to study the structural effects induced on cell membranes, particularly that of human erythrocytes. Auranofin was incubated with intact erythrocytes and molecular models of the erythrocyte membrane. The latter consisted of multibilayers of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), phospholipids classes located in the outer and inner monolayers of the human erythrocyte membrane, respectively. This report presents evidence in order that auranofin interacts with red cell membranes as follows: a) in scanning electron microscopy studies on human erythrocytes it was observed that auranofin induced shape changes; b) X-ray diffraction studies showed that auranofin induced increasing structural perturbation to DMPC and to a lower extent to DMPE bilayers. Additional experiments were performed in human neuroblastoma cells SH-SY5Y. A statistically significant decrease of cell viability was observed.
author	SUWALSKY,MARIO GONZÁLEZ,RAQUEL VILLENA,FERNANDO BOLOGNIN,SILVIA
author_facet	SUWALSKY,MARIO GONZÁLEZ,RAQUEL VILLENA,FERNANDO BOLOGNIN,SILVIA
author_sort	SUWALSKY,MARIO
title	STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
title_short	STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
title_full	STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
title_fullStr	STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
title_full_unstemmed	STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS
title_sort	structural effects of the au(i) drug auranofin on cell membranes and molecular models
publisher	Sociedad Chilena de Química
publishDate	2013
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072013000400021
work_keys_str_mv	AT suwalskymario structuraleffectsoftheauidrugauranofinoncellmembranesandmolecularmodels AT gonzalezraquel structuraleffectsoftheauidrugauranofinoncellmembranesandmolecularmodels AT villenafernando structuraleffectsoftheauidrugauranofinoncellmembranesandmolecularmodels AT bologninsilvia structuraleffectsoftheauidrugauranofinoncellmembranesandmolecularmodels
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STRUCTURAL EFFECTS OF THE AU(I) DRUG AURANOFIN ON CELL MEMBRANES AND MOLECULAR MODELS

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