ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 &...

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Main Authors: IBACACHE,JUANA ANDREA, VALDERRAMA,JAIME A, ARANCIBIA,VERÓNICA, THEODULOZ,CRISTINA, MUCCIOLI,GIULIO G, BENITES,JULIO
Language:English
Published: Sociedad Chilena de Química 2016
Subjects:
Isoquinolinequinones
half-wave potentials
MTT assay
antiproliferative activity
Online Access:http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400008
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http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400008

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