ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 &...

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Autores principales:	IBACACHE,JUANA ANDREA, VALDERRAMA,JAIME A, ARANCIBIA,VERÓNICA, THEODULOZ,CRISTINA, MUCCIOLI,GIULIO G, BENITES,JULIO
Lenguaje:	English
Publicado:	Sociedad Chilena de Química 2016
Materias:	Isoquinolinequinones half-wave potentials MTT assay antiproliferative activity
Acceso en línea:	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400008
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spelling	oai:scielo:S0717-970720160004000082017-01-16ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONESIBACACHE,JUANA ANDREAVALDERRAMA,JAIME AARANCIBIA,VERÓNICATHEODULOZ,CRISTINAMUCCIOLI,GIULIO GBENITES,JULIO Isoquinolinequinones half-wave potentials MTT assay antiproliferative activity A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 μM. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line.info:eu-repo/semantics/openAccessSociedad Chilena de QuímicaJournal of the Chilean Chemical Society v.61 n.4 20162016-12-01text/htmlhttp://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400008en10.4067/S0717-97072016000400008
institution	Scielo Chile
collection	Scielo Chile
language	English
topic	Isoquinolinequinones half-wave potentials MTT assay antiproliferative activity
spellingShingle	Isoquinolinequinones half-wave potentials MTT assay antiproliferative activity IBACACHE,JUANA ANDREA VALDERRAMA,JAIME A ARANCIBIA,VERÓNICA THEODULOZ,CRISTINA MUCCIOLI,GIULIO G BENITES,JULIO ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
description	A variety of 6-bromine-containing 7-anilino-1-arylisoquinolinequinones 2a-g were synthesized to evaluate their half-wave potentials and in vitro antiproliferative activity on gastric and leukemia cancer cell lines. The new compounds displayed significant IC50 values in the range: 1.31 to 11.04 μM. The structure activity relationship analysis of the new series suggest that the antiproliferative activity is dependent, in part, on the push-pull electronic effects of the nitrogen and bromine substituents inserted into the redox fragment of the 1-arylisoquinolinequinone scaffold. Linear regression analysis provided satisfactory relationships between the log IC50 and ClogP values for the AGS gastric cancer cell line.
author	IBACACHE,JUANA ANDREA VALDERRAMA,JAIME A ARANCIBIA,VERÓNICA THEODULOZ,CRISTINA MUCCIOLI,GIULIO G BENITES,JULIO
author_facet	IBACACHE,JUANA ANDREA VALDERRAMA,JAIME A ARANCIBIA,VERÓNICA THEODULOZ,CRISTINA MUCCIOLI,GIULIO G BENITES,JULIO
author_sort	IBACACHE,JUANA ANDREA
title	ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
title_short	ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
title_full	ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
title_fullStr	ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
title_full_unstemmed	ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES
title_sort	antiproliferative activity of new 6-bromine derivatives of 7-anilino-1-arylisoquinolinequinones
publisher	Sociedad Chilena de Química
publishDate	2016
url	http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-97072016000400008
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ANTIPROLIFERATIVE ACTIVITY OF NEW 6-BROMINE DERIVATIVES OF 7-ANILINO-1-ARYLISOQUINOLINEQUINONES

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