CK1BP Reduces α-Synuclein Oligomerization and Aggregation Independent of Serine 129 Phosphorylation

por Lea Elsholz, Yasmine Wasser, Patrick Ziegler, Pardes Habib, Aaron Voigt
Publicado 2021

Mechanistic Insight from Preclinical Models of Parkinson’s Disease Could Help Redirect Clinical Trial Efforts in GDNF Therapy

por Karen M. Delgado-Minjares, Daniel Martinez-Fong, Irma A. Martínez-Dávila, Cecilia Bañuelos, M. E. Gutierrez-Castillo, Víctor Manuel Blanco-Alvarez, Maria-del-Carmen Cardenas-Aguayo, José Luna-Muñoz, Mar Pacheco-Herrero, Luis O. Soto-Rojas
Publicado 2021

α-synuclein interaction with zero-valent iron nanoparticles accelerates structural rearrangement into amyloid-susceptible structure with increased cytotoxic tendency

por Tahaei Gilan SS, Yahya Rayat D, Mustafa TA, Aziz FM, Shahpasand K, Akhtari K, Salihi A, Abou-Zied OK, Falahati M
Publicado 2019

Graphene-Based Nanoparticles as Potential Treatment Options for Parkinson’s Disease: A Molecular Dynamics Study

por Alimohammadi E, Khedri M, Miri Jahromi A, Maleki R, Rezaian M
Publicado 2020

Effect of superparamagnetic nanoparticles coated with various electric charges on α-synuclein and β-amyloid proteins fibrillation process

por Javdani N, Rahpeyma SS, Ghasemi Y, Raheb J
Publicado 2019

Peptide-Based Vaccines for Neurodegenerative Diseases: Recent Endeavors and Future Perspectives

por Vyronia Vassilakopoulou, Chrysoula-Evangelia Karachaliou, Alexandra Evangelou, Christos Zikos, Evangelia Livaniou
Publicado 2021

Alpha-Synuclein Induced Immune Cells Activation and Associated Therapy in Parkinson’s Disease

por Ruichen Su, Tian Zhou
Publicado 2021

Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein

por Charlotte F. Brzozowski, Baraa A. Hijaz, Vijay Singh, Nolwazi Z. Gcwensa, Kaela Kelly, Edward S. Boyden, Andrew B. West, Deblina Sarkar, Laura A. Volpicelli-Daley
Publicado 2021

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds

por Jennifer A. Macdonald, John L. Chen, Masami Masuda-Suzukake, Manuel Schweighauser, Zane Jaunmuktane, Thomas Warner, Janice L. Holton, Annabelle Grossman, Richard Berks, Isabelle Lavenir, Michel Goedert
Publicado 2021

Investigation of the effects of carbon-based nanomaterials on A53T alpha-synuclein aggregation using a whole-cell recombinant biosensor

por Mohammadi S, Nikkhah M, Hosseinkhani S
Publicado 2017

Commentary: Dopamine-Dependent Early Synaptic and Motor Dysfunctions Induced by α-Synuclein in the Nigrostriatal Circuit

por Jiahui Zhang, Heng Liu, Hong Jiang
Publicado 2021

Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagno...

por Afaf El-Ansary, Manan Alhakbany, Abeer Aldbass, Hanan Qasem, Sarah Al-Mazidi, Ramesa Shafi Bhat, Laila Al-Ayadhi
Publicado 2021

Association between Sleep, Alzheimer’s, and Parkinson’s Disease

por Sumire Matsumoto, Tomomi Tsunematsu
Publicado 2021

ABBV-0805, a novel antibody selective for soluble aggregated α-synuclein, prolongs lifespan and prevents buildup of α-synuclein pathology in mouse models of Parkinson's disease

por Eva Nordström, Fredrik Eriksson, Jessica Sigvardson, Malin Johannesson, Alex Kasrayan, Martina Jones-Kostalla, Paulina Appelkvist, Linda Söderberg, Patrik Nygren, Magdalena Blom, Adeline Rachalski, Karin Nordenankar, Olof Zachrisson, Ebba Amandius, Gunilla Osswald, Mikael Moge, Martin Ingelsson, Joakim Bergström, Lars Lannfelt, Christer Möller, Marco Giorgetti, Johanna Fälting
Publicado 2021

Assessing Plasma Levels of α-Synuclein and Neurofilament Light Chain by Different Blood Preparation Methods

por Kuo-Hsuan Chang, Kou-Chen Liu, Kou-Chen Liu, Chao-Sung Lai, Chao-Sung Lai, Chao-Sung Lai, Shieh-Yueh Yang, Chiung-Mei Chen
Publicado 2021

Tyrosine 136 phosphorylation of α-synuclein aggregates in the Lewy body dementia brain: involvement of serine 129 phosphorylation by casein kinase 2

por Kazunori Sano, Yasushi Iwasaki, Yuta Yamashita, Keiichi Irie, Masato Hosokawa, Katsuya Satoh, Kenichi Mishima
Publicado 2021

Effects of the Toxic Metals Arsenite and Cadmium on α-Synuclein Aggregation In Vitro and in Cells

por Emma Lorentzon, Istvan Horvath, Ranjeet Kumar, Joana Isabel Rodrigues, Markus J. Tamás, Pernilla Wittung-Stafshede
Publicado 2021

Molecular chaperones and Parkinson's disease

por Shenglan Hu, Jieqiong Tan, Lixia Qin, Lingling Lv, Weiqian Yan, Hainan Zhang, BeiSha Tang, Chunyu Wang
Publicado 2021

COMPARISON EFFECT BETWEEN PEGAGAN (Centella asiatica) EXTRACT AND PRAMIPEXOLE TOWARD LOCOMOTOR ACTIVITIES, α - SYNUCLEIN, AND NRF2 EXPRESSION IN ZEBRAFISH PARKINSON MODEL

por Ayu Trisnawati, Anasrulloh Anasrulloh, Sri Budhi Rianawati, Husnul Khotimah, Mulyohadi Ali, Budi Susetya
Publicado 2019

TLR2 and TLR4 in Parkinson’s disease pathogenesis: the environment takes a toll on the gut

por Anastazja M. Gorecki, Chidozie C. Anyaegbu, Ryan S. Anderton
Publicado 2021