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  1. 22781
    MYC dephosphorylation by the PP1/PNUTS phosphatase complex regulates chromatin binding and protein stability
    “...Deregulated MYC activity is oncogenic and is deregulated in a large fraction of human cancers. Here...”
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  2. 22782
    Molecular analysis of aggressive renal cell carcinoma with unclassified histology reveals distinct subsets
    “..., the authors examine this group of unclassified renal cancers using genomics techniques and identify further...”
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  3. 22783
    Oncogenic herpesvirus KSHV triggers hallmarks of alternative lengthening of telomeres
    “...~15% of cancers induce alternative lengthening of telomeres (ALT) to activate telomere maintenance...”
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  4. 22784
    DNA damage sensitivity of SWI/SNF-deficient cells depends on TFIIH subunit p62/GTF2H1
    “...SWI/SNF genes are commonly found to be mutated in different cancers. Here the authors report...”
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  5. 22785
    HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma
    “...HOPX is a transcription factor epigenetically silenced in several cancers. Here the authors...”
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  6. 22786
    Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors
    “... mitochondrial dynamics are frequently amplified in human cancers, and that these alterations are associated...”
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  7. 22787
    Steroid receptor coactivator 3 (SRC-3/AIB1) is enriched and functional in mouse and human Tregs
    “... is an oncogene in multiple cancers and is capable of potentiating numerous transcription factors in a wide...”
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  8. 22788
    FBXO22 degrades nuclear PTEN to promote tumorigenesis
    “...Loss of nuclear PTEN is associated with aggressive cancers. Here the authors show that nuclear PTEN...”
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  9. 22789
    Loss of testosterone impairs anti-tumor neutrophil function
    “...It is known that there are sex differences in the incidence and prognosis of certain cancers...”
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  10. 22790
    Endosomal phosphatidylserine is critical for the YAP signalling pathway in proliferating cells
    “... the malignancy of various cancers, however its regulation is not fully understood. Here the authors show...”
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  11. 22791
    Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia
    “...Loss of function mutations of NSD1 occur in blood cancers. Here, the authors report that NSD1 loss...”
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  12. 22792
    Synthetic viability by BRCA2 and PARP1/ARTD1 deficiencies
    “... associated cancers. Here the authors show that olaparib can contribute to synthetic viability of cells...”
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  13. 22793
    Circulating tumour DNA from the cerebrospinal fluid allows the characterisation and monitoring of medulloblastoma
    “...Non-invasive and precise methods are critical for monitoring paediatric brain cancers. Here...”
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  14. 22794
    Chromatin accessibility promotes hematopoietic and leukemia stem cell activity
    “... are frequently seen in cancers. Here, the authors show that the chromatin accessibility regulator HMGN1 - which...”
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  15. 22795
    Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas
    “...% of cancers that have been associated with mutations in ATRX. Here the authors reveal a functional role...”
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  16. 22796
    Lipid order and charge protect killer T cells from accidental death
    “...Cytotoxic T lymphocytes (CTLs) eliminate virus-infected and cancerous cells by secreting the pore...”
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  17. 22797
    Evolution of multiple cell clones over a 29-year period of a CLL patient
    “...Studying the genetic progression of many cancers is difficult as longitudinal samples are rarely...”
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  18. 22798
    A splicing isoform of TEAD4 attenuates the Hippo–YAP signalling to inhibit tumour proliferation
    “...The Hippo/Yap signalling pathway is found deregulated in several cancers. Here, the authors uncover...”
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  19. 22799
    Long-read sequencing unveils IGH-DUX4 translocation into the silenced IGH allele in B-cell acute lymphoblastic leukemia
    “...The IGH@ proto-oncogene translocation is a known genomic driver in several blood cancers. Here...”
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  20. 22800
    The spatial organization of intra-tumour heterogeneity and evolutionary trajectories of metastases in hepatocellular carcinoma
    “...Hepatocellular carcinoma has one of the poorest survival rates amongst cancers. Here, the authors...”
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