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  1. 22821
    Modulating multi-functional ERK complexes by covalent targeting of a recruitment site in vivo
    “...The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult...”
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  2. 22822
    Deubiquitinase USP13 dictates MCL1 stability and sensitivity to BH3 mimetic inhibitors
    “... in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its...”
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  3. 22823
    Tet2 loss leads to hypermutagenicity in haematopoietic stem/progenitor cells
    “...TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null...”
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  4. 22824
    Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapy
    “...Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1...”
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  5. 22825
    DHHC9-mediated GLUT1 S-palmitoylation promotes glioblastoma glycolysis and tumorigenesis
    “...The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour...”
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  6. 22826
    USP52 acts as a deubiquitinase and promotes histone chaperone ASF1A stabilization
    “...Histone chaperone ASF1A is often dysregulated in cancers, however the regulation of its abundance...”
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  7. 22827
    PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma
    “...Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse...”
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  8. 22828
    RNF167 activates mTORC1 and promotes tumorigenesis by targeting CASTOR1 for ubiquitination and degradation
    “... dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1...”
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  9. 22829
    TRIB3 promotes MYC-associated lymphoma development through suppression of UBE3B-mediated MYC degradation
    “...c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a...”
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  10. 22830
    High prevalence of focal and multi-focal somatic genetic variants in the human brain
    “...Similar to cancers, somatic mutations might lead to neurodegenerative diseases. Here, the authors...”
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  11. 22831
    Wnt pathway activation by ADP-ribosylation
    “... in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein...”
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  12. 22832
    Vasculogenic mimicry formation in EBV-associated epithelial malignancies
    “... angiogenesis. Here, the authors show EBV promotes vasculogenic mimicry in EBV associated epithelial cancers via...”
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  13. 22833
    Attenuation of RNA polymerase II pausing mitigates BRCA1-associated R-loop accumulation and tumorigenesis
    “...The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells...”
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  14. 22834
    Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effects
    “... cancers. Here, the authors show that combinatorial responses of two anticancer drugs can be accurately...”
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  15. 22835
    High grade serous ovarian carcinomas originate in the fallopian tube
    “... the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers...”
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  16. 22836
    Autophagy of the m6A mRNA demethylase FTO is impaired by low-level arsenic exposure to promote tumorigenesis
    “...RNA m6A demethylase FTO has oncogenic roles in cancers. Here the authors show that chronic low...”
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  17. 22837
    Myc targeted CDK18 promotes ATR and homologous recombination to mediate PARP inhibitor resistance in glioblastoma
    “...PARP inhibitors are mainly used to treat BRCA1/2 mutated cancers. Here, the authors show that MYC...”
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  18. 22838
    A truncating mutation in the autophagy gene UVRAG drives inflammation and tumorigenesis in mice
    “... form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein...”
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  19. 22839
    KRAS regulation by small non-coding RNAs and SNARE proteins
    “...Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS...”
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  20. 22840
    Atomic structure of the Epstein-Barr virus portal
    “... and several types of cancers. Here the authors describe a high-resolution atomic structure of the EBV portal...”
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