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22821por Tamer S. Kaoud, William H. Johnson, Nancy D. Ebelt, Andrea Piserchio, Diana Zamora-Olivares, Sabrina X. Van Ravenstein, Jacey R. Pridgen, Ramakrishna Edupuganti, Rachel Sammons, Micael Cano, Mangalika Warthaka, Matthew Harger, Clint D. J. Tavares, Jihyun Park, Mohamed F. Radwan, Pengyu Ren, Eric V. Anslyn, Kenneth Y. Tsai, Ranajeet Ghose, Kevin N. Dalby“...The ERK signalling pathway is activated in many cancers, however ERK1 and ERK2 are difficult...”
Publicado 2019
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22822por Shengzhe Zhang, Meiying Zhang, Ying Jing, Xia Yin, Pengfei Ma, Zhenfeng Zhang, Xiaojie Wang, Wen Di, Guanglei Zhuang“... in cancers. Here, the authors show that MCL1’s stability is regulated by deubiquitinase USP13, and its...”
Publicado 2018
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22823por Feng Pan, Thomas S. Wingo, Zhigang Zhao, Rui Gao, Hideki Makishima, Guangbo Qu, Li Lin, Miao Yu, Janice R. Ortega, Jiapeng Wang, Aziz Nazha, Li Chen, Bing Yao, Can Liu, Shi Chen, Ophelia Weeks, Hongyu Ni, Brittany Lynn Phillips, Suming Huang, Jianlong Wang, Chuan He, Guo-Min Li, Tomas Radivoyevitch, Iannis Aifantis, Jaroslaw P. Maciejewski, Feng-Chun Yang, Peng Jin, Mingjiang Xu“...TET2 catalyses DNA demethylation and is mutated in various blood cancers; in particularTet2null...”
Publicado 2017
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22824Rap1 regulates hematopoietic stem cell survival and affects oncogenesis and response to chemotherapypor Ekta Khattar, Kyaw Ze Ya Maung, Chen Li Chew, Arkasubhra Ghosh, Michelle Meng Huang Mok, Pei Lee, Jun Zhang, Wei Hong Jeff Chor, Gökhan Cildir, Chelsia Qiuxia Wang, Nur Khairiah Mohd-Ismail, Desmond Wai Loon Chin, Soo Chin Lee, Henry Yang, Yong-Jae Shin, Do-Hyun Nam, Liming Chen, Alan Prem Kumar, Lih Wen Deng, Masahito Ikawa, Jayantha Gunaratne, Motomi Osato, Vinay Tergaonkar“...Rap1 is a telomeric protein that is highly expressed in cancers. Here, the authors show that Rap1...”
Publicado 2019
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22825por Zhenxing Zhang, Xin Li, Fan Yang, Chao Chen, Ping Liu, Yi Ren, Pengkai Sun, Zixiong Wang, Yongping You, Yi-Xin Zeng, Xinjian Li“...The glucose transporter GLUT1 is upregulated in multiple cancers and may contribute to tumour...”
Publicado 2021
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22826por Shangda Yang, Ling Liu, Cheng Cao, Nan Song, Yuejiao Wang, Shuai Ma, Qi Zhang, Na Yu, Xiang Ding, Fuquan Yang, Shanshan Tian, Kai Zhang, Tao Sun, Jie Yang, Zhi Yao, Shaoyuan Wu, Lei Shi“...Histone chaperone ASF1A is often dysregulated in cancers, however the regulation of its abundance...”
Publicado 2018
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22827por Nathan R. Fons, Ranjini K. Sundaram, Gregory A. Breuer, Sen Peng, Ryan L. McLean, Aravind N. Kalathil, Mark S. Schmidt, Diana M. Carvalho, Alan Mackay, Chris Jones, Ángel M. Carcaboso, Javad Nazarian, Michael E. Berens, Charles Brenner, Ranjit S. Bindra“...Mutations in the Protein Phosphatase PPM1D are oncogenic in certain cancers including diffuse...”
Publicado 2019
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22828por Tingting Li, Xian Wang, Enguo Ju, Suzane Ramos da Silva, Luping Chen, Xinquan Zhang, Shan Wei, Shou-Jiang Gao“... dysregulated in cancers. Here the authors show that AKT and E3 ubiquitin ligase RNF167 mediate CASTOR1...”
Publicado 2021
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22829por Ke Li, Feng Wang, Zhao-na Yang, Ting-ting Zhang, Yu-fen Yuan, Chen-xi Zhao, Zaiwuli Yeerjiang, Bing Cui, Fang Hua, Xiao-xi Lv, Xiao-wei Zhang, Jiao-jiao Yu, Shan-shan Liu, Jin-mei Yu, Shuang Shang, Yang Xiao, Zhuo-wei Hu“...c-MYC is often deregulated in human cancers including lymphomas. Here, the authors show that a...”
Publicado 2020
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22830por Michael J. Keogh, Wei Wei, Juvid Aryaman, Lauren Walker, Jelle van den Ameele, Jon Coxhead, Ian Wilson, Matthew Bashton, Jon Beck, John West, Richard Chen, Christian Haudenschild, Gabor Bartha, Shujun Luo, Chris M. Morris, Nick S. Jones, Johannes Attems, Patrick F. Chinnery“...Similar to cancers, somatic mutations might lead to neurodegenerative diseases. Here, the authors...”
Publicado 2018
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22831por Eungi Yang, Ofelia Tacchelly-Benites, Zhenghan Wang, Michael P. Randall, Ai Tian, Hassina Benchabane, Sarah Freemantle, Claudio Pikielny, Nicholas S. Tolwinski, Ethan Lee, Yashi Ahmed“... in several cancers. Here the authors implicate Tankyrase—previously shown to target the scaffolding protein...”
Publicado 2016
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22832por Tong Xiang, Yu-Xin Lin, Wenlong Ma, Hao-Jiong Zhang, Ke-Ming Chen, Gui-Ping He, Xiao Zhang, Miao Xu, Qi-Sheng Feng, Ming-Yuan Chen, Mu-Sheng Zeng, Yi-Xin Zeng, Lin Feng“... angiogenesis. Here, the authors show EBV promotes vasculogenic mimicry in EBV associated epithelial cancers via...”
Publicado 2018
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22833por Xiaowen Zhang, Huai-Chin Chiang, Yao Wang, Chi Zhang, Sabrina Smith, Xiayan Zhao, Sreejith J. Nair, Joel Michalek, Ismail Jatoi, Meeghan Lautner, Boyce Oliver, Howard Wang, Anna Petit, Teresa Soler, Joan Brunet, Francesca Mateo, Miguel Angel Pujana, Elizabeth Poggi, Krysta Chaldekas, Claudine Isaacs, Beth N. Peshkin, Oscar Ochoa, Frederic Chedin, Constantine Theoharis, Lu-Zhe Sun, Tyler J. Curiel, Richard Elledge, Victor X. Jin, Yanfen Hu, Rong Li“...The vast majority of BRCA1-driven breast cancers derive from luminal progenitor cells...”
Publicado 2017
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22834Leveraging multi-way interactions for systematic prediction of pre-clinical drug combination effectspor Heli Julkunen, Anna Cichonska, Prson Gautam, Sandor Szedmak, Jane Douat, Tapio Pahikkala, Tero Aittokallio, Juho Rousu“... cancers. Here, the authors show that combinatorial responses of two anticancer drugs can be accurately...”
Publicado 2020
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22835por S. Intidhar Labidi-Galy, Eniko Papp, Dorothy Hallberg, Noushin Niknafs, Vilmos Adleff, Michael Noe, Rohit Bhattacharya, Marian Novak, Siân Jones, Jillian Phallen, Carolyn A. Hruban, Michelle S. Hirsch, Douglas I. Lin, Lauren Schwartz, Cecile L. Maire, Jean-Christophe Tille, Michaela Bowden, Ayse Ayhan, Laura D. Wood, Robert B. Scharpf, Robert Kurman, Tian-Li Wang, Ie-Ming Shih, Rachel Karchin, Ronny Drapkin, Victor E. Velculescu“... the fallopian tube. Here, the authors analyze genetic aberrances in fallopian tube lesions, ovarian cancers...”
Publicado 2017
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22836por Yan-Hong Cui, Seungwon Yang, Jiangbo Wei, Christopher R. Shea, Wen Zhong, Fang Wang, Palak Shah, Muhammad G. Kibriya, Xiaolong Cui, Habibul Ahsan, Chuan He, Yu-Ying He“...RNA m6A demethylase FTO has oncogenic roles in cancers. Here the authors show that chronic low...”
Publicado 2021
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22837por Jian-Fang Ning, Monica Stanciu, Melissa R. Humphrey, Joshua Gorham, Hiroko Wakimoto, Reiko Nishihara, Jacqueline Lees, Lee Zou, Robert L. Martuza, Hiroaki Wakimoto, Samuel D. Rabkin“...PARP inhibitors are mainly used to treat BRCA1/2 mutated cancers. Here, the authors show that MYC...”
Publicado 2019
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22838por Christine Quach, Ying Song, Hongrui Guo, Shun Li, Hadi Maazi, Marshall Fung, Nathaniel Sands, Douglas O’Connell, Sara Restrepo-Vassalli, Billy Chai, Dali Nemecio, Vasu Punj, Omid Akbari, Gregory E. Idos, Shannon M. Mumenthaler, Nancy Wu, Sue Ellen Martin, Ashley Hagiya, James Hicks, Hengmin Cui, Chengyu Liang“... form in cancers. Here, the authors use a mouse model that inducibly express this truncated protein...”
Publicado 2019
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22839por Yonglu Che, Zurab Siprashvili, Joanna R. Kovalski, Tiffany Jiang, Glenn Wozniak, Lara Elcavage, Paul A. Khavari“...Small nucleolar RNAs, SNORD50A/B are frequently deleted in cancers and can inhibit KRAS...”
Publicado 2019
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22840por Cristina Machón, Montserrat Fàbrega-Ferrer, Daming Zhou, Ana Cuervo, José L. Carrascosa, David I. Stuart, Miquel Coll“... and several types of cancers. Here the authors describe a high-resolution atomic structure of the EBV portal...”
Publicado 2019
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