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  1. 22861
    A cell-autonomous tumour suppressor role of RAF1 in hepatocarcinogenesis
    “... cancers. Here, the authors using a mouse model of HCC and clinical data describe an unexpected...”
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  2. 22862
    Structural basis of mechano-chemical coupling by the mitotic kinesin KIF14
    “... defects and several cancers. Here the authors use cryoEM to determine 20 structures of KIF14 constructs...”
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  3. 22863
    An ErbB2/c-Src axis links bioenergetics with PRC2 translation to drive epigenetic reprogramming and mammary tumorigenesis
    “...Polycomb Repressor Complex 2 (PRC2) is frequently up-regulated in cancers. Here, the authors show...”
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  4. 22864
    Tumor-infiltrating mast cells are associated with resistance to anti-PD-1 therapy
    por Rajasekharan Somasundaram, Thomas Connelly, Robin Choi, Hyeree Choi, Anastasia Samarkina, Ling Li, Elizabeth Gregorio, Yeqing Chen, Rohit Thakur, Mohamed Abdel-Mohsen, Marilda Beqiri, Meaghan Kiernan, Michela Perego, Fang Wang, Min Xiao, Patricia Brafford, Xue Yang, Xiaowei Xu, Anthony Secreto, Gwenn Danet-Desnoyers, Daniel Traum, Klaus H. Kaestner, Alexander C. Huang, Denitsa Hristova, Joshua Wang, Mizuho Fukunaga-Kalabis, Clemens Krepler, Fang Ping-Chen, Xiangyang Zhou, Alexis Gutierrez, Vito W. Rebecca, Prashanthi Vonteddu, Farokh Dotiwala, Shashi Bala, Sonali Majumdar, Harsh Dweep, Jayamanna Wickramasinghe, Andrew V. Kossenkov, Jorge Reyes-Arbujas, Kenisha Santiago, Tran Nguyen, Johannes Griss, Frederick Keeney, James Hayden, Brian J. Gavin, David Weiner, Luis J. Montaner, Qin Liu, Lukas Peiffer, Jürgen Becker, Elizabeth M. Burton, Michael A. Davies, Michael T. Tetzlaff, Kar Muthumani, Jennifer A. Wargo, Dmitry Gabrilovich, Meenhard Herlyn
    Publicado 2021
    “...Immune checkpoint therapies (ICT) are promising for treating various cancers, but response rates...”
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  5. 22865
    EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
    “...Epigallocatechin gallate (EGCG) is a catechin flavonoid which induces apoptosis in cancerous cells...”
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  6. 22866
    Development of a genetic sensor that eliminates p53 deficient cells
    “...TP53 is mutated in many cancers, a system to detect and selectively eliminate p53 mutant cells...”
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  7. 22867
    Inhibition of mTORC1 by lncRNA H19 via disrupting 4E-BP1/Raptor interaction in pituitary tumours
    “...LncRNA H19 has been shown to be aberrantly expressed in different cancers. Here, the authors show...”
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  8. 22868
    miR-181a initiates and perpetuates oncogenic transformation through the regulation of innate immune signaling
    “...The majority of high grade serous ovarian cancers originate from fallopian tube secretory...”
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  9. 22869
    Identification of a novel chalcone derivative that inhibits Notch signaling in T-cell acute lymphoblastic leukemia
    “...Abstract Notch signaling is considered a rational target in the therapy of several cancers...”
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  10. 22870
    A double helical motif in OCIAD2 is essential for its localization, interactions and STAT3 activation
    “.../Asrij and OCIAD2, are implicated in several cancers and neurodegenerative diseases. While Asrij has a...”
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  11. 22871
    The Use of Inhibitors of Tyrosine Kinase in Paediatric Haemato-Oncology—When and Why?
    “... significant improvement in the outcome of childhood cancers. However, there are still groups of patients who...”
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  12. 22872
    Spatiotemporally Differential Expression of HER (Human Epithelial Growth Factor Receptor)-2 with Sexual Dimorphism in Submandibular Gland of Mice
    “... proliferation, apoptosis and differentiation which are regulated by proto-oncogene products in cancerous cells...”
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  13. 22873
    BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization
    “... in a variety of cancers. Here, the authors report the structure of BMI1 bound to the protein PHC2...”
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  14. 22874
    The targetable kinase PIM1 drives ALK inhibitor resistance in high-risk neuroblastoma independent of MYCN status
    “...), but its acquired resistance is reported in non-small cell lung cancers. Here, the authors have found PIM1...”
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  15. 22875
    BCL11A interacts with SOX2 to control the expression of epigenetic regulators in lung squamous carcinoma
    “...Amongst the non-small cell lung cancers, to date, lung squamous cell carcinoma remains the most...”
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  16. 22876
    ∆133p53 isoform promotes tumour invasion and metastasis via interleukin-6 activation of JAK-STAT and RhoA-ROCK signalling
    “...Aberrant expression of the Δ133p53 isoform is linked to many cancers. Here, the authors utilise a...”
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  17. 22877
    Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors
    por Julie George, Vonn Walter, Martin Peifer, Ludmil B. Alexandrov, Danila Seidel, Frauke Leenders, Lukas Maas, Christian Müller, Ilona Dahmen, Tiffany M. Delhomme, Maude Ardin, Noemie Leblay, Graham Byrnes, Ruping Sun, Aurélien De Reynies, Anne McLeer-Florin, Graziella Bosco, Florian Malchers, Roopika Menon, Janine Altmüller, Christian Becker, Peter Nürnberg, Viktor Achter, Ulrich Lang, Peter M. Schneider, Magdalena Bogus, Matthew G. Soloway, Matthew D. Wilkerson, Yupeng Cun, James D. McKay, Denis Moro-Sibilot, Christian G. Brambilla, Sylvie Lantuejoul, Nicolas Lemaitre, Alex Soltermann, Walter Weder, Verena Tischler, Odd Terje Brustugun, Marius Lund-Iversen, Åslaug Helland, Steinar Solberg, Sascha Ansén, Gavin Wright, Benjamin Solomon, Luca Roz, Ugo Pastorino, Iver Petersen, Joachim H. Clement, Jörg Sänger, Jürgen Wolf, Martin Vingron, Thomas Zander, Sven Perner, William D. Travis, Stefan A. Haas, Magali Olivier, Matthieu Foll, Reinhard Büttner, David Neil Hayes, Elisabeth Brambilla, Lynnette Fernandez-Cuesta, Roman K. Thomas
    Publicado 2018
    “.... Here, the authors show LCNECs represent a distinct transcriptional subgroup among lung cancers...”
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  18. 22878
    Structural basis of oncogenic histone H3K27M inhibition of human polycomb repressive complex 2
    “... to the oncogenic H3K27M mutant, and suggest a mechanism for its potency in childhood brain cancers....”
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  19. 22879
    HNF4A defines tissue-specific circadian rhythms by beaconing BMAL1::CLOCK chromatin binding and shaping the rhythmic chromatin landscape
    por Meng Qu, Han Qu, Zhenyu Jia, Steve A. Kay
    Publicado 2021
    “... tissues and is reprogrammed in cancers, but how specificity is governed is not known. Here the authors...”
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  20. 22880
    The H3.3K27M oncohistone antagonizes reprogramming in Drosophila.
    por Kami Ahmad, Steven Henikoff
    Publicado 2021
    “... of previously silenced genes, and such developmental aberrations are thought to underlie a variety of cancers...”
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