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  1. 17941
    Single-cell transcriptomics reveals multi-step adaptations to endocrine therapy
    “... cancer. Here, the authors identify a rare subpopulation of cells that drive resistance following...”
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  2. 17942
    Complex vectorial optics through gradient index lens cascades
    “... and form the basis of a Müller matrix polarimeter with potential for endoscopic label-free cancer...”
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  3. 17943
    Small tandem DNA duplications result from CST-guided Pol α-primase action at DNA break termini
    “...Error-prone repair of DNA double-strand breaks have been implied to cause cancer-associated genome...”
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  4. 17944
    Interactome analysis reveals that lncRNA HULC promotes aerobic glycolysis through LDHA and PKM2
    “... in liver cancer), which is shown to interact with glycolytic enzymes and modulate their activity....”
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  5. 17945
    OTUD5 cooperates with TRIM25 in transcriptional regulation and tumor progression via deubiquitination activity
    “..., the authors perform an RNAi screen and identify that the deubiquitinase OTUD5 suppresses cancer growth in a...”
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  6. 17946
    Phenotypic profiling with a living biobank of primary rhabdomyosarcoma unravels disease heterogeneity and AKT sensitivity
    “...Patient-specific precision medicine approaches are important for future cancer therapies. Here...”
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  7. 17947
    Structural basis of ALC1/CHD1L autoinhibition and the mechanism of activation by the nucleosome
    por Li Wang, Kangjing Chen, Zhucheng Chen
    Publicado 2021
    “...The oncogenic chromatin remodeler ALC1 (amplification in liver cancer 1), also known as CHD1L...”
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  8. 17948
    Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance
    “...The molecular mechanisms underlying cancer cell radioresistance need to be elucidated...”
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  9. 17949
    Escape from nonsense-mediated decay associates with anti-tumor immunogenicity
    “...The transcripts generated by frameshifts and indels in cancer are frequently degraded by nonsense...”
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  10. 17950
    Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth
    “...Mechanisms governing adaptation of breast cancer to the brain metastatic microenvironment...”
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  11. 17951
    A combination strategy targeting enhancer plasticity exerts synergistic lethality against BETi-resistant leukemia cells
    “...Epigenetic changes can drive drug resistance in cancer. Here, the authors show that in BET...”
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  12. 17952
    Degree and site of chromosomal instability define its oncogenic potential
    “...Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known...”
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  13. 17953
    Selective targeting of IL-2 to NKG2D bearing cells for improved immunotherapy
    “...High-affinity IL-2Rα expressed by Tregs mitigates the potential of IL-2 use in cancer therapy. Here...”
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  14. 17954
    Atezolizumab in combination with bevacizumab enhances antigen-specific T-cell migration in metastatic renal cell carcinoma
    “...Cancer immunotherapy can be used in combination with other therapies for a better response. Here...”
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  15. 17955
    p53-mediated control of aspartate-asparagine homeostasis dictates LKB1 activity and modulates cell survival
    “...Cancer cells can produce asparagine, yet both the regulation and biological functions of asparagine...”
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  16. 17956
    Whole-genome sequencing reveals genomic signatures associated with the inflammatory microenvironments in Chinese NSCLC patients
    “...The distinct genomic and epidemiological features of Chinese lung cancer patients suggest...”
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  17. 17957
    ETS transcription factors induce a unique UV damage signature that drives recurrent mutagenesis in melanoma
    “...Many factors contribute to mutation hotspots in cancer cells. Here the authors map UV damage...”
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  18. 17958
    Targeting glutamine metabolism slows soft tissue sarcoma growth
    “...Glutamine is an energetic source required for the proliferation of cancer cells. Here, the authors...”
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  19. 17959
    The anti-malarial atovaquone increases radiosensitivity by alleviating tumour hypoxia
    “... demonstrate that the anti-malarial, atovaquone, reduces the oxygen consumption rate of cancer cells...”
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  20. 17960
    The deubiquitylase OTUD3 stabilizes GRP78 and promotes lung tumorigenesis
    “... show that OTUD3 also has an oncogenic role in lung cancer by stabilizing the glucose-regulated protein...”
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