Immunogenicity and efficacy of mRNA COVID-19 vaccine MRT5500 in preclinical animal models

por Kirill V. Kalnin, Timothy Plitnik, Michael Kishko, Jinrong Zhang, Donghui Zhang, Adrien Beauvais, Natalie G. Anosova, Tim Tibbitts, Josh DiNapoli, Gregory Ulinski, Peter Piepenhagen, Sheila M. Cummings, Dinesh S. Bangari, Susan Ryan, Po-Wei D. Huang, James Huleatt, Deanne Vincent, Katherine Fries, Shrirang Karve, Rebecca Goldman, Hardip Gopani, Anusha Dias, Khang Tran, Minnie Zacharia, Xiaobo Gu, Lianne Boeglin, Jonathan Abysalh, Jorel Vargas, Angela Beaulieu, Monic Shah, Travis Jeannotte, Kimberly Gillis, Sudha Chivukula, Ron Swearingen, Victoria Landolfi, Tong-Ming Fu, Frank DeRosa, Danilo Casimiro
Publicado 2021

Selectively targeting haemagglutinin antigen to chicken CD83 receptor induces faster and stronger immunity against avian influenza

por Angita Shrestha, Jean-Remy Sadeyen, Deimante Lukosaityte, Pengxiang Chang, Adrian Smith, Marielle Van Hulten, Munir Iqbal
Publicado 2021

A single dose, BCG-adjuvanted COVID-19 vaccine provides sterilising immunity against SARS-CoV-2 infection

por Claudio Counoupas, Matt D. Johansen, Alberto O. Stella, Duc H. Nguyen, Angela L. Ferguson, Anupriya Aggarwal, Nayan D. Bhattacharyya, Alice Grey, Owen Hutchings, Karishma Patel, Rezwan Siddiquee, Erica L. Stewart, Carl G. Feng, Nicole G. Hansbro, Umaimainthan Palendira, Megan C. Steain, Bernadette M. Saunders, Jason K. K. Low, Joel P. Mackay, Anthony D. Kelleher, Warwick J. Britton, Stuart G. Turville, Philip M. Hansbro, James A. Triccas
Publicado 2021

Immune response against SARS-CoV-2 variants: the role of neutralization assays

por Alicja Maria Chmielewska, Anna Czarnota, Krystyna Bieńkowska-Szewczyk, Katarzyna Grzyb
Publicado 2021

Epitope-coated polymer particles elicit neutralising antibodies against Plasmodium falciparum sporozoites

por Benjamin J. Evert, Shuxiong Chen, Robyn McConville, Ryan W. J. Steel, Julie Healer, Justin A. Boddey, Lucas Huntimer, Bernd H. A. Rehm
Publicado 2021

Mucosal vaccination induces protection against SARS-CoV-2 in the absence of detectable neutralizing antibodies

por Chaojie Zhong, Hongjie Xia, Awadalkareem Adam, Binbin Wang, Renee L. Hajnik, Yuejin Liang, Grace H. Rafael, Jing Zou, Xiaofang Wang, Jiaren Sun, Lynn Soong, Alan D. T. Barrett, Scott C. Weaver, Pei-Yong Shi, Tian Wang, Haitao Hu
Publicado 2021

A third SARS-CoV-2 spike vaccination improves neutralization of variants-of-concern

por Mitch Brinkkemper, Philip J. M. Brouwer, Pauline Maisonnasse, Marloes Grobben, Tom G. Caniels, Meliawati Poniman, Judith A. Burger, Ilja Bontjer, Melissa Oomen, Joey H. Bouhuijs, Cynthia A. van der Linden, Julien Villaudy, Yme U. van der Velden, Kwinten Sliepen, Marit J. van Gils, Roger Le Grand, Rogier W. Sanders
Publicado 2021

Gut microbiota imbalance in colorectal cancer patients, the risk factor of COVID-19 mortality

por Changjing Cai, Xiangyang Zhang, Yihan Liu, Edward Shen, Ziyang Feng, Cao Guo, Ying Han, Yanhong Ouyang, Hong Shen
Publicado 2021

MVA vector expression of SARS-CoV-2 spike protein and protection of adult Syrian hamsters against SARS-CoV-2 challenge

por Clement A. Meseda, Charles B. Stauft, Prabhuanand Selvaraj, Christopher Z. Lien, Cyntia Pedro, Ivette A. Nuñez, Amy M. Woerner, Tony T. Wang, Jerry P. Weir
Publicado 2021

Importance of medication reconciliation in cancer patients

por Ali Elbeddini, Anthony To, Yasamin Tayefehchamani, Cindy Xin Wen
Publicado 2021

Molecular interactions between parasite and mosquito during midgut invasion as targets to block malaria transmission

por Yacob Keleta, Julian Ramelow, Liwang Cui, Jun Li
Publicado 2021

Unique features of a recombinant haemagglutinin influenza vaccine that influence vaccine performance

por Arun B. Arunachalam, Penny Post, Deborah Rudin
Publicado 2021

A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/β-catenin signaling pathway to promote gastric cancer progression

por Yin Peng, Yidan Xu, Xiaojing Zhang, Shiqi Deng, Yuan Yuan, Xiaonuan Luo, Md Tofazzal Hossain, Xiaohui Zhu, Kaining Du, Fan Hu, Yang Chen, Shanshan Chang, Xianling Feng, Xinmin Fan, Hassan Ashktorab, Duane Smoot, Stephen J. Meltzer, Gangqiang Hou, Yanjie Wei, Song Li, Ying Qin, Zhe Jin
Publicado 2021

Curcumin suppresses the progression of gastric cancer by regulating circ_0056618/miR-194-5p axis

por Li Shan, Zhang Lihai, Li Shuhua, Zhao Hengyi, Chen Yonggang
Publicado 2021

Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis

por Li Minghao, Zhuang Jianbin, Kang Di, Chen Yuzhuo, Song Weiliang
Publicado 2021

Big Data, artificial intelligence and laboratory medicine: time for integration

por Gruson Damien
Publicado 2021

Down-regulation of IGHG1 enhances Protoporphyrin IX accumulation and inhibits hemin biosynthesis in colorectal cancer by suppressing the MEK-FECH axis

por Yang Guangjian, Li Gang, Du Xuemei, Zhou Wenting, Zou Xiaohong, Liu Yuanfu, Lv Hong, Li Zhenjiang
Publicado 2021

Big Data, inteligencia artificial y medicina de laboratorio: la hora de la integración

por Gruson Damien
Publicado 2021

Transcriptomic Profiling Revealed Plexin A2 Downregulation With Migration and Invasion Alteration in Dacarbazine-Treated Primary Melanoma Cells

por Anna Tyumentseva, Anna Tyumentseva, Anton Averchuk, Nadezhda Palkina, Ivan Zinchenko, Anton Moshev, Andrey Savchenko, Tatiana Ruksha
Publicado 2021

Subspecies Niche Specialization in the Oral Microbiome Is Associated with Nasopharyngeal Carcinoma Risk

por Justine W. Debelius, Tingting Huang, Yonglin Cai, Alexander Ploner, Donal Barrett, Xiaoying Zhou, Xue Xiao, Yancheng Li, Jian Liao, Yuming Zheng, Guangwu Huang, Hans-Olov Adami, Yi Zeng, Zhe Zhang, Weimin Ye
Publicado 2020