Mostrando 701 - 720 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.06s Limitar resultados
  1. 701
    Aldosterone Impairs Mitochondrial Function in Human Cardiac Fibroblasts via A-Kinase Anchor Protein 12
    “...-activated receptor gamma coactivator 1-alpha (PGC-1α) expressions in human cardiac fibroblasts. CRISPR/Cas9...”
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  2. 702
    Enhancement of trans-cleavage activity of Cas12a with engineered crRNA enables amplified nucleic acid detection
    “...CRISPR-Cas12a based detection systems can be sensitive down to the picomolar range. Here...”
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  3. 703
    Automated multiplex genome-scale engineering in yeast
    “... for genome-scale engineering inSaccharomyces cerevisiaeusing CRISPR-Cas and RNAi....”
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  4. 704
    Engineered CRISPRa enables programmable eukaryote-like gene activation in bacteria
    por Yang Liu, Xinyi Wan, Baojun Wang
    Publicado 2019
    “...CRISPR activation strategies in bacteria are limited due to the reliance on σ70 promoters. Here...”
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  5. 705
    Immunogenomic engineering of a plug-and-(dis)play hybridoma platform
    “... in hybridomas using CRISPR-Cas9....”
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  6. 706
    CRISPaint allows modular base-specific gene tagging using a ligase-4-dependent mechanism
    “... the authors describe CRISPaint, a universal tagging system using CRISPR-Cas9 to insert genes in an NHEJ...”
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  7. 707
    Efficient allelic-drive in Drosophila
    “...Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors...”
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  8. 708
    Integration and exchange of split dCas9 domains for transcriptional controls in mammalian cells
    por Dacheng Ma, Shuguang Peng, Zhen Xie
    Publicado 2016
    “...Molecular engineering of Cas9 has the potential to expand the application of CRISPR-Cas technology...”
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  9. 709
    Long-term genomic coevolution of host-parasite interaction in the natural environment
    “... systems is limited. Here, the authors show changes in the resistance and CRISPR loci of bacteria...”
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  10. 710
    One-step generation of multiple gene knock-outs in the diatom Phaeodactylum tricornutum by DNA-free genome editing
    “... CRISPR-Cas9 and counter-selectable markers....”
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  11. 711
    Real-time observation of DNA recognition and rejection by the RNA-guided endonuclease Cas9
    “...CRISPR-Cas9 has enabled an unprecedented ability to manipulate the genome yet it is still poorly...”
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  12. 712
    Targeting repair pathways with small molecules increases precise genome editing in pluripotent stem cells
    por Stephan Riesenberg, Tomislav Maricic
    Publicado 2018
    “... substitution and gene integration in CRISPR-mediated genome editing. Here the authors introduce CRISPY, a mix...”
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  13. 713
    A thermostable Cas9 with increased lifetime in human plasma
    “...While current CRISPR-Cas9 tools have revolutionized genome editing, they are not suitable...”
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  14. 714
    Biased genome editing using the local accumulation of DSB repair molecules system
    “...Genome editing using CRISPR can be enhanced by manipulating DNA double-strand break repair pathways...”
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  15. 715
    Internal guide RNA interactions interfere with Cas9-mediated cleavage
    “...While the CRISPR-Cas9 system has revolutionised molecular biology, it is still a mystery why...”
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  16. 716
    Synergistic gene editing in human iPS cells via cell cycle and DNA repair modulation
    por Thomas L. Maurissen, Knut Woltjen
    Publicado 2020
    “...Precision editing with CRISPR-Cas9 often suffers from poor efficiency. Here the authors identify...”
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  17. 717
    In silico analysis enabling informed design for genome editing in medicinal cannabis; gene families and variant characterisation.
    “... genome editing using CRISPR, Zinc Fingers and TALENs technically difficult. Evaluation of allele...”
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  18. 718
    S100A8 expression in oviduct mucosal epithelial cells is regulated by estrogen and affects mucosal immune homeostasis.
    “... the clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 method...”
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  19. 719
    SMARCB1 deletion in atypical teratoid rhabdoid tumors results in human endogenous retrovirus K (HML-2) expression
    “... downregulated HML-2 expression. Further, targeted downregulation of HML-2 transcription via CRISPR-dCas9 coupled...”
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  20. 720
    Mitofusin-2 modulates the epithelial to mesenchymal transition in thyroid cancer progression
    “... expression in thyroid cancer by analyzing TCGA data. In vitro and in vivo, MFN2 was knocked out using CRISPR...”
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