Mostrando 741 - 760 Resultados de 1,137 Para Buscar '"CRISPR"', tiempo de consulta: 0.08s Limitar resultados
  1. 741
    Structural roles of guide RNAs in the nuclease activity of Cas9 endonuclease
    “...In bacteria, CRISPR-Cas9 identifies and cleaves the target DNA with the assistance of a tracrRNA...”
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  2. 742
    Pooled library screening with multiplexed Cpf1 library
    “...AsCpf1 is an alternative nuclease to Cas9 for CRISPR mediated genome engineering. Here the authors...”
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  3. 743
    CTCF driven TERRA transcription facilitates completion of telomere DNA replication
    “..., by using CRISPR/Cas9, mutate CTCF-binding sites at start site of TERRA transcripts and find...”
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  4. 744
    Accelerating target deconvolution for therapeutic antibody candidates using highly parallelized genome editing
    “..., the authors investigate a deconvolution approach based on pooled CRISPR Cas9 to achieve 97% deconvolution...”
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  5. 745
    Engineer chimeric Cas9 to expand PAM recognition based on evolutionary information
    “...The genomic locations that can be targeted for editing by CRISPR are limited by the presence...”
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  6. 746
    CtIP fusion to Cas9 enhances transgene integration by homology-dependent repair
    “...The integration of exogenous DNA into the genome using CRISPR–Cas9 often presents a challenge...”
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  7. 747
    TRPS1 shapes YAP/TEAD-dependent transcription in breast cancer cells
    “... tumour suppressive functions. Here, the authors perform an unbiased genome wide CRISPR screen...”
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  8. 748
    Targeting of NLRP3 inflammasome with gene editing for the amelioration of inflammatory diseases
    “..., the authors inactivate NLRP3 in macrophages using CRISPR/Cas9 encapsulated in nanoparticles, and show...”
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  9. 749
    In trans paired nicking triggers seamless genome editing without double-stranded DNA cutting
    “...CRISPR-Cas9-based gene editing involves double-strand breaks at target sequences, which are often...”
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  10. 750
    R-Spondin chromosome rearrangements drive Wnt-dependent tumour initiation and maintenance in the intestine
    “.... Here, using CRISPR-mediated genome editing, the authors show that endogenous Rspo2 or Rspo3 chromosome...”
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  11. 751
    Ex vivo visualization of RNA polymerase III-specific gene activity with electron microscopy
    “...Manger, Ermel, and Frangakis report the use of CRISPR/Cas9 to stably insert multiple copies of a...”
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  12. 752
    Non-homologous DNA increases gene disruption efficiency by altering DNA repair outcomes
    “...CRISPR-Cas9 mediated gene editing has begun to revolutionize molecular biology, but editing...”
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  13. 753
    Engineering and optimising deaminase fusions for genome editing
    “... and recently CRISPR-Cas9 targeted APOBECs have been demonstrated. Here the authors design zinc-finger and TALE...”
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  14. 754
    Homologous recombination-dependent repair of telomeric DSBs in proliferating human cells
    “... damage in telomeres is repaired is poorly understood. Here the authors use CRISPR-Cas9 to induce DNA...”
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  15. 755
    Microhomology-assisted scarless genome editing in human iPSCs
    “... achieve scarless excision by CRISPR-Cas9 and microhomology mediated end-joining....”
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  16. 756
    ARMMs as a versatile platform for intracellular delivery of macromolecules
    “... platform for packaging and delivery of a myriad of molecules, including p53, RNAs and CRISPR-Cas9....”
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  17. 757
    Stable Cells with NF-κB-ZsGreen Fused Genes Created by TALEN Editing and Homology Directed Repair for Screening Anti-inflammation Drugs
    por Zhang S, Luo T, Wang J
    Publicado 2021
    “...T, HepG2, and PANC1) with both TALEN and CRISPR. The edited NF-κB genes were repaired by homology...”
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  18. 758
    Sensing Host Arginine Is Essential for <italic toggle="yes">Leishmania</italic> Parasites’ Intracellular Development
    “.... CRISPR/Cas9-mediated disruption of the AAP3 locus yielded mutants that retain a basal level of arginine...”
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  19. 759
    Defining the ATPome reveals cross-optimization of metabolic pathways
    “..., the authors apply a genome-wide CRISPR screen to define genes that increase or decrease ATP levels to define...”
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  20. 760
    Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility
    “... genome-wide CRISPR screens in Toxoplasma gondii and identify that the putative transporter Tmem14c...”
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