Mostrando 1 - 20 Resultados de 63 Para Buscar '"Huntingtin"', tiempo de consulta: 0.09s Limitar resultados
  1. 1
    Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
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  2. 2
    Author Correction: Truncation of mutant huntingtin in knock-in mice demonstrates exon1 huntingtin is a key pathogenic form
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  3. 3
    Normal aging modulates the neurotoxicity of mutant huntingtin.
    “... caused by an abnormal expansion of a polyglutamine tract in the protein huntingtin (Htt), the role...”
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  4. 4
    A high-throughput screening to identify small molecules that suppress huntingtin promoter activity or activate huntingtin-antisense promoter activity
    “... in exon 1 of huntingtin (HTT). While there are currently no disease-modifying treatments for HD, recent...”
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  5. 5
    Regulatory mechanisms of incomplete huntingtin mRNA splicing
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  6. 6
    The Cytotoxicity and Clearance of Mutant Huntingtin and Other Misfolded Proteins
    por Austin Folger, Yanchang Wang
    Publicado 2021
    Materias: “...mutated Huntingtin...”
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  7. 7
    Huntingtin's function in axonal transport is conserved in Drosophila melanogaster.
    “... by an abnormal polyglutamine expansion in the N-terminal part of the huntingtin (HTT) protein. HTT is a large...”
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  8. 8
    Salivary levels of total huntingtin are elevated in Huntington’s disease patients
    “... huntingtin (Htt), a potentially useful biomarker for this disease. In the current study, we determined...”
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  9. 9
    Analysis of mutant and total huntingtin expression in Huntington’s disease murine models
    “... by the expansion of a polyglutamine region within the huntingtin (HTT) protein, but there is still an incomplete...”
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  10. 10
    Polyglutamine expansion affects huntingtin conformation in multiple Huntington’s disease models
    “... or recombinantly expressed huntingtin (HTT) proteins affects their conformational properties in a manner dependent...”
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  11. 11
    Huntingtin fibrils with different toxicity, structure, and seeding potential can be interconverted
    “...Huntingtin exon-1 (HTTex1) consists of a N-terminal N17 domain, the disease causing polyQ domain...”
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  12. 12
    Pharmacological characterization of mutant huntingtin aggregate-directed PET imaging tracer candidates
    “... exon of the huntingtin (HTT) gene coding for the huntingtin (HTT) protein. The misfolding...”
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  13. 13
    Promoters are differentially sensitive to N-terminal mutant huntingtin-mediated transcriptional repression.
    “... copy of the huntingtin gene. Mutant huntingtin protein (mHtt) contains an expanded polyglutamine repeat...”
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  14. 14
    Amyloid-mediated sequestration of essential proteins contributes to mutant huntingtin toxicity in yeast.
    “... aggregation and toxicity of a huntingtin (htt) protein with an expanded polyglutamine region strictly depend...”
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  15. 15
    Nuclear and cytoplasmic huntingtin inclusions exhibit distinct biochemical composition, interactome and ultrastructural properties
    “...The mechanisms underlying Huntingtin protein (Htt) aggregation are not fully understood. Here...”
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  16. 16
    Threshold concentration and random collision determine the growth of the huntingtin inclusion from a stable core
    “...Pei et al. explore the mechanism underlying growth of mutant huntingtin inclusions in yeast cells...”
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  17. 17
    Silencing Srsf6 does not modulate incomplete splicing of the huntingtin gene in Huntington’s disease models
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  18. 18
    Mutant Huntingtin stalls ribosomes and represses protein synthesis in a cellular model of Huntington disease
    “... tract in the huntingtin (mHtt) protein. Here the authors suggest that mHtt promotes ribosome stalling...”
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  19. 19
    Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin.
    “... with intracellular growth and proliferation related signaling cascades. Huntingtin (Htt), a ubiquitously expressed...”
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  20. 20
    Cryo-electron tomography provides topological insights into mutant huntingtin exon 1 and polyQ aggregates
    “... huntingtin (mHTT) and polyglutamine-only (polyQ) filaments in large aggregates free of stains, fixatives...”
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