BRD4-mediated repression of p53 is a target for combination therapy in AML

por Anne-Louise Latif, Ashley Newcombe, Sha Li, Kathryn Gilroy, Neil A. Robertson, Xue Lei, Helen J. S. Stewart, John Cole, Maria Terradas Terradas, Loveena Rishi, Lynn McGarry, Claire McKeeve, Claire Reid, William Clark, Joana Campos, Kristina Kirschner, Andrew Davis, Jonathan Lopez, Jun-ichi Sakamaki, Jennifer P. Morton, Kevin M. Ryan, Stephen W. G. Tait, Sheela A. Abraham, Tessa Holyoake, Brian Higgins, Xu Huang, Karen Blyth, Mhairi Copland, Timothy J. T. Chevassut, Karen Keeshan, Peter D. Adams
Publicado 2021

The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer

por Emily Golden, Rabab Rashwan, Eleanor A. Woodward, Agustin Sgro, Edina Wang, Anabel Sorolla, Charlene Waryah, Wan Jun Tie, Elisabet Cuyàs, Magdalena Ratajska, Iwona Kardaś, Piotr Kozlowski, Elizabeth K. M. Johnstone, Heng B. See, Ciara Duffy, Jeremy Parry, Kim A. Lagerborg, Piotr Czapiewski, Javier A. Menendez, Adam Gorczyński, Bartosz Wasag, Kevin D. G. Pfleger, Christina Curtis, Bum-Kyu Lee, Jonghwan Kim, Joseph Cursons, Nathan J. Pavlos, Wojciech Biernat, Mohit Jain, Andrew J. Woo, Andrew Redfern, Pilar Blancafort
Publicado 2021

Sex and APOE ε4 genotype modify the Alzheimer’s disease serum metabolome

por Matthias Arnold, Kwangsik Nho, Alexandra Kueider-Paisley, Tyler Massaro, Kevin Huynh, Barbara Brauner, Siamak MahmoudianDehkordi, Gregory Louie, M. Arthur Moseley, J. Will Thompson, Lisa St John-Williams, Jessica D. Tenenbaum, Colette Blach, Rui Chang, Roberta D. Brinton, Rebecca Baillie, Xianlin Han, John Q. Trojanowski, Leslie M. Shaw, Ralph Martins, Michael W. Weiner, Eugenia Trushina, Jon B. Toledo, Peter J. Meikle, David A. Bennett, Jan Krumsiek, P. Murali Doraiswamy, Andrew J. Saykin, Rima Kaddurah-Daouk, Gabi Kastenmüller
Publicado 2020

Dendrogenin A drives LXR to trigger lethal autophagy in cancers

por Gregory Segala, Marion David, Philippe de Medina, Mathias C. Poirot, Nizar Serhan, François Vergez, Aurelie Mougel, Estelle Saland, Kevin Carayon, Julie Leignadier, Nicolas Caron, Maud Voisin, Julia Cherier, Laetitia Ligat, Frederic Lopez, Emmanuel Noguer, Arnaud Rives, Bruno Payré, Talal al Saati, Antonin Lamaziere, Gaëtan Despres, Jean-Marc Lobaccaro, Silvere Baron, Cecile Demur, Fabienne de Toni, Clément Larrue, Helena Boutzen, Fabienne Thomas, Jean-Emmanuel Sarry, Marie Tosolini, Didier Picard, Michel Record, Christian Récher, Marc Poirot, Sandrine Silvente-Poirot
Publicado 2017

Transcriptomic analysis links diverse hypothalamic cell types to fibroblast growth factor 1-induced sustained diabetes remission

por Marie A. Bentsen, Dylan M. Rausch, Zaman Mirzadeh, Kenjiro Muta, Jarrad M. Scarlett, Jenny M. Brown, Vicente Herranz-Pérez, Arian F. Baquero, Jonatan Thompson, Kimberly M. Alonge, Chelsea L. Faber, Karl J. Kaiyala, Camdin Bennett, Charles Pyke, Cecilia Ratner, Kristoffer L. Egerod, Birgitte Holst, Thomas H. Meek, Burak Kutlu, Yu Zhang, Thomas Sparso, Kevin L. Grove, Gregory J. Morton, Birgitte R. Kornum, José-Manuel García-Verdugo, Anna Secher, Rasmus Jorgensen, Michael W. Schwartz, Tune H. Pers
Publicado 2020

Interaction of Klebsiella pneumoniae with tissue macrophages in a mouse infection model and ex-vivo pig organ perfusions: an exploratory investigation

por Joseph J Wanford, PhD, Ryan G Hames, BSc, David Carreno, PhD, Zydrune Jasiunaite, BSc, Wen Y Chung, PhD, Fabio Arena, MD, Vincenzo Di Pilato, PhD, Kornelis Straatman, PhD, Kevin West, ProfPhD, Robeena Farzand, PhD, Mariagrazia Pizza, MA, Luisa Martinez-Pomares, PhD, Peter W Andrew, ProfPhD, E Richard Moxon, ProfFRS, Ashley R Dennison, ProfMD, Gian Maria Rossolini, ProfMD, Marco R Oggioni, ProfMD
Publicado 2021

Aberrant enhancer hypomethylation contributes to hepatic carcinogenesis through global transcriptional reprogramming

por Lei Xiong, Feng Wu, Qiong Wu, Liangliang Xu, Otto K. Cheung, Wei Kang, Myth T. Mok, Lemuel L. M. Szeto, Cheuk-Yin Lun, Raymond W. Lung, Jinglin Zhang, Ken H. Yu, Sau-Dan Lee, Guangcun Huang, Chiou-Miin Wang, Joseph Liu, Zhuo Yu, Dae-Yeul Yu, Jian-Liang Chou, Wan-Hong Huang, Bo Feng, Yue-Sun Cheung, Paul B. Lai, Patrick Tan, Nathalie Wong, Michael W. Chan, Tim H. Huang, Kevin Y. Yip, Alfred S. Cheng, Ka-Fai To
Publicado 2019

Tracking attosecond electronic coherences using phase-manipulated extreme ultraviolet pulses

por Andreas Wituschek, Lukas Bruder, Enrico Allaria, Ulrich Bangert, Marcel Binz, Roberto Borghes, Carlo Callegari, Giulio Cerullo, Paolo Cinquegrana, Luca Giannessi, Miltcho Danailov, Alexander Demidovich, Michele Di Fraia, Marcel Drabbels, Raimund Feifel, Tim Laarmann, Rupert Michiels, Najmeh Sadat Mirian, Marcel Mudrich, Ivaylo Nikolov, Finn H. O’Shea, Giuseppe Penco, Paolo Piseri, Oksana Plekan, Kevin Charles Prince, Andreas Przystawik, Primož Rebernik Ribič, Giuseppe Sansone, Paolo Sigalotti, Simone Spampinati, Carlo Spezzani, Richard James Squibb, Stefano Stranges, Daniel Uhl, Frank Stienkemeier
Publicado 2020

Intraamniotic Zika virus inoculation of pregnant rhesus macaques produces fetal neurologic disease

por Lark L. Coffey, Rebekah I. Keesler, Patricia A. Pesavento, Kevin Woolard, Anil Singapuri, Jennifer Watanabe, Christina Cruzen, Kari L. Christe, Jodie Usachenko, JoAnn Yee, Victoria A. Heng, Eliza Bliss-Moreau, J. Rachel Reader, Wilhelm von Morgenland, Anne M. Gibbons, Kenneth Jackson, Amir Ardeshir, Holly Heimsath, Sallie Permar, Paranthaman Senthamaraikannan, Pietro Presicce, Suhas G. Kallapur, Jeffrey M. Linnen, Kui Gao, Robert Orr, Tracy MacGill, Michelle McClure, Richard McFarland, John H. Morrison, Koen K. A. Van Rompay
Publicado 2018

Intranasal vaccination with a Newcastle disease virus-vectored vaccine protects hamsters from SARS-CoV-2 infection and disease

por Bryce M. Warner, Lisa A. Santry, Alexander Leacy, Mable Chan, Phuc H. Pham, Robert Vendramelli, Yanlong Pei, Nikesh Tailor, Emelissa Valcourt, Anders Leung, Shihua He, Bryan D. Griffin, Jonathan Audet, Marnie Willman, Kevin Tierney, Alixandra Albietz, Kathy L. Frost, Jacob G.E. Yates, Robert C. Mould, Lily Chan, Yeganeh Mehrani, Jason P. Knapp, Jessica A. Minott, Logan Banadyga, David Safronetz, Heidi Wood, Stephanie Booth, Pierre P. Major, Byram W. Bridle, Leonardo Susta, Darwyn Kobasa, Sarah K. Wootton
Publicado 2021

Circulating tumor DNA is readily detectable among Ghanaian breast cancer patients supporting non-invasive cancer genomic studies in Africa

por Samuel Terkper Ahuno, Anna-Lisa Doebley, Thomas U. Ahearn, Joel Yarney, Nicholas Titiloye, Nancy Hamel, Ernest Adjei, Joe-Nat Clegg-Lamptey, Lawrence Edusei, Baffour Awuah, Xiaoyu Song, Verna Vanderpuye, Mustapha Abubakar, Maire Duggan, Daniel G. Stover, Kofi Nyarko, John M. S. Bartlett, Francis Aitpillah, Daniel Ansong, Kevin L. Gardner, Felix Andy Boateng, Anne M. Bowcock, Carlos Caldas, William D. Foulkes, Seth Wiafe, Beatrice Wiafe-Addai, Montserrat Garcia-Closas, Alexander Kwarteng, Gavin Ha, Jonine D. Figueroa, Paz Polak, the Ghana Breast Health Study Team
Publicado 2021

Pathologic gene network rewiring implicates PPP1R3A as a central regulator in pressure overload heart failure

por Pablo Cordero, Victoria N. Parikh, Elizabeth T. Chin, Ayca Erbilgin, Michael J. Gloudemans, Ching Shang, Yong Huang, Alex C. Chang, Kevin S. Smith, Frederick Dewey, Kathia Zaleta, Michael Morley, Jeff Brandimarto, Nicole Glazer, Daryl Waggott, Aleksandra Pavlovic, Mingming Zhao, Christine S. Moravec, W. H. Wilson Tang, Jamie Skreen, Christine Malloy, Sridhar Hannenhalli, Hongzhe Li, Scott Ritter, Mingyao Li, Daniel Bernstein, Andrew Connolly, Hakon Hakonarson, Aldons J. Lusis, Kenneth B. Margulies, Anna A. Depaoli-Roach, Stephen B. Montgomery, Matthew T. Wheeler, Thomas Cappola, Euan A. Ashley
Publicado 2019

Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.

por Marilyn C Cornelis, Keri L Monda, Kai Yu, Nina Paynter, Elizabeth M Azzato, Siiri N Bennett, Sonja I Berndt, Eric Boerwinkle, Stephen Chanock, Nilanjan Chatterjee, David Couper, Gary Curhan, Gerardo Heiss, Frank B Hu, David J Hunter, Kevin Jacobs, Majken K Jensen, Peter Kraft, Maria Teresa Landi, Jennifer A Nettleton, Mark P Purdue, Preetha Rajaraman, Eric B Rimm, Lynda M Rose, Nathaniel Rothman, Debra Silverman, Rachael Stolzenberg-Solomon, Amy Subar, Meredith Yeager, Daniel I Chasman, Rob M van Dam, Neil E Caporaso
Publicado 2011

Methylation of all BRCA1 copies predicts response to the PARP inhibitor rucaparib in ovarian carcinoma

por Olga Kondrashova, Monique Topp, Ksenija Nesic, Elizabeth Lieschke, Gwo-Yaw Ho, Maria I. Harrell, Giada V. Zapparoli, Alison Hadley, Robert Holian, Emma Boehm, Valerie Heong, Elaine Sanij, Richard B. Pearson, John J. Krais, Neil Johnson, Orla McNally, Sumitra Ananda, Kathryn Alsop, Karla J. Hutt, Scott H. Kaufmann, Kevin K. Lin, Thomas C. Harding, Nadia Traficante, Australian Ovarian Cancer Study (AOCS), Anna deFazio, Iain A. McNeish, David D. Bowtell, Elizabeth M. Swisher, Alexander Dobrovic, Matthew J. Wakefield, Clare L. Scott
Publicado 2018

Machine learning application for the prediction of SARS-CoV-2 infection using blood tests and chest radiograph

por Richard Du, Efstratios D. Tsougenis, Joshua W. K. Ho, Joyce K. Y. Chan, Keith W. H. Chiu, Benjamin X. H. Fang, Ming Yen Ng, Siu-Ting Leung, Christine S. Y. Lo, Ho-Yuen F. Wong, Hiu-Yin S. Lam, Long-Fung J. Chiu, Tiffany Y So, Ka Tak Wong, Yiu Chung I. Wong, Kevin Yu, Yiu-Cheong Yeung, Thomas Chik, Joanna W. K. Pang, Abraham Ka-chung Wai, Michael D. Kuo, Tina P. W. Lam, Pek-Lan Khong, Ngai-Tseung Cheung, Varut Vardhanabhuti
Publicado 2021

The copy number variation and stroke (CaNVAS) risk and outcome study.

por John W Cole, Taiwo Adigun, Rufus Akinyemi, Onoja Matthew Akpa, Steven Bell, Bowang Chen, Jordi Jimenez Conde, Uxue Lazcano Dobao, Israel Fernandez, Myriam Fornage, Cristina Gallego-Fabrega, Christina Jern, Michael Krawczak, Arne Lindgren, Hugh S Markus, Olle Melander, Mayowa Owolabi, Kristina Schlicht, Martin Söderholm, Vinodh Srinivasasainagendra, Carolina Soriano Tárraga, Martin Stenman, Hemant Tiwari, Margaret Corasaniti, Natalie Fecteau, Beth Guizzardi, Haley Lopez, Kevin Nguyen, Brady Gaynor, Timothy O'Connor, O Colin Stine, Steven J Kittner, Patrick McArdle, Braxton D Mitchell, Huichun Xu, Caspar Grond-Ginsbach
Publicado 2021

Multiple forest attributes underpin the supply of multiple ecosystem services

por María R. Felipe-Lucia, Santiago Soliveres, Caterina Penone, Peter Manning, Fons van der Plas, Steffen Boch, Daniel Prati, Christian Ammer, Peter Schall, Martin M. Gossner, Jürgen Bauhus, Francois Buscot, Stefan Blaser, Nico Blüthgen, Angel de Frutos, Martin Ehbrecht, Kevin Frank, Kezia Goldmann, Falk Hänsel, Kirsten Jung, Tiemo Kahl, Thomas Nauss, Yvonne Oelmann, Rodica Pena, Andrea Polle, Swen Renner, Michael Schloter, Ingo Schöning, Marion Schrumpf, Ernst-Detlef Schulze, Emily Solly, Elisabeth Sorkau, Barbara Stempfhuber, Marco Tschapka, Wolfgang W. Weisser, Tesfaye Wubet, Markus Fischer, Eric Allan
Publicado 2018

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

por Adeline C. Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne-Marie Zeeman, Caitlin A. Cooper, Kevin S. W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K. S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H. M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani
Publicado 2019

New Method for Measuring Angle-Resolved Phases in Photoemission

por Daehyun You, Kiyoshi Ueda, Elena V. Gryzlova, Alexei N. Grum-Grzhimailo, Maria M. Popova, Ekaterina I. Staroselskaya, Oyunbileg Tugs, Yuki Orimo, Takeshi Sato, Kenichi L. Ishikawa, Paolo Antonio Carpeggiani, Tamás Csizmadia, Miklós Füle, Giuseppe Sansone, Praveen Kumar Maroju, Alessandro D’Elia, Tommaso Mazza, Michael Meyer, Carlo Callegari, Michele Di Fraia, Oksana Plekan, Robert Richter, Luca Giannessi, Enrico Allaria, Giovanni De Ninno, Mauro Trovò, Laura Badano, Bruno Diviacco, Giulio Gaio, David Gauthier, Najmeh Mirian, Giuseppe Penco, Primož Rebernik Ribič, Simone Spampinati, Carlo Spezzani, Kevin C. Prince
Publicado 2020

Complex Attosecond Waveform Synthesis at FEL FERMI

por Praveen Kumar Maroju, Cesare Grazioli, Michele Di Fraia, Matteo Moioli, Dominik Ertel, Hamed Ahmadi, Oksana Plekan, Paola Finetti, Enrico Allaria, Luca Giannessi, Giovanni De Ninno, Alberto A. Lutman, Richard J. Squibb, Raimund Feifel, Paolo Carpeggiani, Maurizio Reduzzi, Tommaso Mazza, Michael Meyer, Samuel Bengtsson, Neven Ibrakovic, Emma Rose Simpson, Johan Mauritsson, Tamás Csizmadia, Mathieu Dumergue, Sergei Kühn, Harshitha Nandiga Gopalakrishnan, Daehyun You, Kiyoshi Ueda, Marie Labeye, Jens Egebjerg Bækhøj, Kenneth J. Schafer, Elena V. Gryzlova, Alexei N. Grum-Grzhimailo, Kevin C. Prince, Carlo Callegari, Giuseppe Sansone
Publicado 2021