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  1. 3361
    Evolution of linked avirulence effectors in Leptosphaeria maculans is affected by genomic environment and exposure to resistance genes in host plants.
    “... interact in a 'gene for gene' manner whereby plant resistance (R) genes are complementary to pathogen...”
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  2. 3362
    The extracytoplasmic domain of the Mycobacterium tuberculosis Ser/Thr kinase PknB binds specific muropeptides and is required for PknB localization.
    “... demonstrate that the extracytoplasmic domain of PknB binds muropeptides in a manner dependent on the presence...”
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  3. 3363
    Functional analysis of N-acetylglucosaminyltransferase-I knockdown in 2D and 3D neuroblastoma cell cultures
    “... modified in a different manner under 2D and 3D cultures. Thus, our results support variations in the N...”
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  4. 3364
    Ash1l methylates Lys36 of histone H3 independently of transcriptional elongation to counteract polycomb silencing.
    “... of either Tip60 or Mof in a region-dependent manner. We also found that Brg1 is another key player involved...”
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  5. 3365
    A simple iterative model accurately captures complex trapline formation by bumblebees across spatial scales and flower arrangements.
    “...Pollinating bees develop foraging circuits (traplines) to visit multiple flowers in a manner...”
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  6. 3366
    Human tumour immune evasion via TGF-β blocks NK cell activation but not survival allowing therapeutic restoration of anti-tumour activity.
    “...) cells are inhibited in a TGF-β dependent manner following chronic contact-dependent interactions...”
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  7. 3367
    Acute insulin stimulation induces phosphorylation of the Na-Cl cotransporter in cultured distal mpkDCT cells and mouse kidney.
    “...-related proline-alanine-rich kinase (SPAK) and NCC in a dose-dependent manner. This insulin-induced...”
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  8. 3368
    RasGAP-derived fragment N increases the resistance of beta cells towards apoptosis in NOD mice and delays the progression from mild to overt diabetes.
    “...-Akt-dependent manner. Fragment N protects various cell types, including insulin-secreting cells...”
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  9. 3369
    The bile acid sensor FXR is required for immune-regulatory activities of TLR-9 in intestinal inflammation.
    “...-dependent manner. Protection against TNBS colitis by CpG, a TLR-9 ligand, was lost in FXR(-/-) mice...”
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  10. 3370
    Irx1 and Irx2 are coordinately expressed and regulated by retinoic acid, TGFβ and FGF signaling during chick hindlimb development.
    “... protein regulated Irx1 and Irx2 in a stage-dependent manner at the interdigital tissue, it inhibited...”
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  11. 3371
    RANKL signaling and osteoclastogenesis is negatively regulated by cardamonin.
    “... differentiation of monocytes to osteoclasts in a dose-dependent and time-dependent manner. We also found...”
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  12. 3372
    TTK/hMPS1 is an attractive therapeutic target for triple-negative breast cancer.
    “... in an anchorage-independent manner. Moreover, we observed that TTK silencing led to an increase in H2AX...”
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  13. 3373
    Development of antipsychotic medications with novel mechanisms of action based on computational modeling of hippocampal neuropathology.
    por Peter J Siekmeier, David P vanMaanen
    Publicado 2013
    “... medications, which were implemented by varying five model parameters, independently, in a graded manner...”
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  14. 3374
    PMS1077 sensitizes TNF-α induced apoptosis in human prostate cancer cells by blocking NF-κB signaling pathway.
    “... in a dose dependent manner. Western blot assay indicated that PMS1077 suppressed the TNF-α induced...”
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  15. 3375
    New clothes for the jasmonic acid receptor COI1: delayed abscission, meristem arrest and apical dominance.
    “... to be evolutionarily divergent functions for COI1 that are governed in an ecotype-dependent manner. Further...”
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  16. 3376
    Efficacy, safety and anticancer activity of protein nanoparticle-based delivery of doxorubicin through intravenous administration in rats.
    “... and bioavailability of the drug in a target-specific manner....”
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  17. 3377
    Singlet oxygen induced products of linoleates, 10- and 12-(Z,E)-hydroxyoctadecadienoic acids (HODE), can be potential biomarkers for early detection of type 2 diabetes.
    “... in a random and destructive manner is considered to play an important role in the pathophysiology of a...”
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  18. 3378
    Anti-Sclerostin antibody inhibits internalization of Sclerostin and Sclerostin-mediated antagonism of Wnt/LRP6 signaling.
    “...-dependent process, and subsequently degraded in a temperature and proteasome-dependent manner. Ectopic...”
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  19. 3379
    Huaier aqueous extract inhibits ovarian cancer cell motility via the AKT/GSK3β/β-catenin pathway.
    “... and late apoptosis in SKOV3, SKOV3.ip1 and Hey cells in a time- and dose-dependent manner. Cell...”
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  20. 3380
    Membrane properties of striatal direct and indirect pathway neurons in mouse and rat slices and their modulation by dopamine.
    “... properties therefore acts in a synergistic manner with previously reported effects of DA on afferent synaptic...”
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