Mostrando 1 - 20 Resultados de 76 Para Buscar '"Mdm2"', tiempo de consulta: 0.12s Limitar resultados
  1. 1
    Tumorogénesis y proteína mdm2
    por Flores P,Carlos, Sobrevia L,Luis
    Publicado 2000
    Materias: “...Mdm2...”
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  2. 2
    Adipose MDM2 regulates systemic insulin sensitivity
    “...53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53...”
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  3. 3
    Structural basis for DNA damage-induced phosphoregulation of MDM2 RING domain
    “...p53 is an important tumor suppressor protein which is regulated by the E3 ubiquitin ligase MDM2...”
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  4. 4
    Mad1 destabilizes p53 by preventing PML from sequestering MDM2
    “... and displacing MDM2 from the PML-MDM2 complex....”
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  5. 5
    The MDM2-p53 pathway is involved in preconditioning-induced neuronal tolerance to ischemia
    “... to neuronal death. The murine double minute 2 gene (MDM2), a p53-specific E3 ubiquitin ligase, is the main...”
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  6. 6
    Regulation of MDM2 E3 ligase-dependent vascular calcification by MSX1/2
    “... ligase activity of a protein called MDM2 induces calcification. Now, following further mouse trials...”
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  7. 7
    MDM2 E3 ligase-mediated ubiquitination and degradation of HDAC1 in vascular calcification
    “... diseases. Here, Kwon et al.show that calcification stimuli induce MDM2- mediated ubiquitination...”
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  8. 8
    Activation of wild-type p53 by MDM2 inhibitors: a new strategy for lymphoma treatment
    por Pujals A, Favre L, Gaulard P, Wiels J
    Publicado 2015
    “... of MDM2, which are potentially relevant for the treatment of B- and T-cell lymphomas. We will describe...”
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  9. 9
    MDM2–MDM4 molecular interaction investigated by atomic force spectroscopy and surface plasmon resonance
    Materias: “...MDM2...”
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  10. 10
    EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction
    “... ubiquitination of p53 by MDM2....”
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  11. 11
    Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
    “... translocation of Nrf2 in chronically infected culture induces Mdm2-mediated retinoblastoma protein (Rb...”
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  12. 12
    TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist
    “... in DIPG tumorigenesis. While MDM2 is a major negative regulator of p53, the efficacy of MDM2 inhibitor has...”
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  13. 13
    The MDM2–p53–pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells
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  14. 14
    Retraction Note: Activation of PERK-Nrf2 oncogenic signaling promotes Mdm2-mediated Rb degradation in persistently infected HCV culture
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  15. 15
    Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana.
    “... mouse double minute 2 (MDM2) is the commonest event in breast cancer. These altered genes usually...”
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  16. 16
    Exosomal lncRNA CHL1-AS1 Derived from Peritoneal Macrophages Promotes the Progression of Endometriosis via the miR-610/MDM2 Axis
    por Liu T, Liu M, Zheng C, Zhang D, Li M, Zhang L
    Publicado 2021
    Materias: “...mdm2...”
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  17. 17
    Expression profile of tumour suppressor protein p53 and its regulator MDM2 in a cohort of breast cancer patients in a Tertiary Hospital in Ghana
    “... mouse double minute 2 (MDM2) is the commonest event in breast cancer. These altered genes usually...”
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  18. 18
    The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
    Materias: “...MDM2...”
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  19. 19
    Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.
    “..., the cell cycle regulator CDC5L, the TP53 transcriptional inactivator MDM2, the DNA helicase RECQL4...”
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  20. 20
    In Vitro Assessment of the Role of p53 on Chemotherapy Treatments in Neuroblastoma Cell Lines
    Materias: “...MDM2...”
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