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  1. 5321
    Deletion of CDKAL1 affects high-fat diet-induced fat accumulation and glucose-stimulated insulin secretion in mice, indicating relevance to diabetes.
    “... function as a critical mediator of the altered metabolism in Cdkal1⁻/⁻ mice. In accordance...”
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  2. 5322
    Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin.
    “...)-146b-5p inhibits NFκB-mediated inflammation by targeted repression of IRAK1 and TNF receptor...”
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  3. 5323
    A Gammaherpesvirus Noncoding RNA Is Essential for Hematogenous Dissemination and Establishment of Peripheral Latency
    “... analyses, we identified TMER4 as a key mediator of virus dissemination. The TMER4 mutant virus replicated...”
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  4. 5324
    RNase L Interacts with Filamin A To Regulate Actin Dynamics and Barrier Function for Viral Entry
    “... and RNase L activation disrupt its association with Filamin A and release RNase L to mediate its canonical...”
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  5. 5325
    Global Spread of Mutant PfCRT and Its Pleiotropic Impact on <named-content content-type="genus-species">Plasmodium falciparum</named-content> Multidrug Resistance and Fitness
    “... observed to mediate lower degrees of resistance to CQ and the first-line drug amodiaquine, while resulting...”
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  6. 5326
    A Noncanonical DNA Damage Checkpoint Response in a Major Fungal Pathogen
    “... Rad53/CHK2 mediates further aspects of checkpoint activation, including cell cycle arrest...”
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  7. 5327
    <italic toggle="yes">Chlamydia trachomatis</italic> Inhibits Homologous Recombination Repair of DNA Breaks by Interfering with PP2A Signaling
    “... downstream signaling, including phosphorylation of MRE11 and NBS1 and checkpoint kinase 2 (Chk2)-mediated...”
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  8. 5328
    Genetic Dissection of the Type VI Secretion System in <italic toggle="yes">Acinetobacter</italic> and Identification of a Novel Peptidoglycan Hydrolase, TagX, Required for Its Biogenesis
    “...-negative bacteria that has emerged as a potent mediator of antibacterial activity during interbacterial...”
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  9. 5329
    Asparagine Deprivation Causes a Reversible Inhibition of Human Cytomegalovirus Acute Virus Replication
    “... range of cellular processes, including the mediator complex, proteasome function, and mRNA splicing...”
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  10. 5330
    A systematic analysis of host factors reveals a Med23-interferon-λ regulatory axis against herpes simplex virus type 1 replication.
    “... Mediator complex, which links specific transcription factors to RNA polymerase II. The anti-viral effect...”
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  11. 5331
    Complement Activation Contributes to Severe Acute Respiratory Syndrome Coronavirus Pathogenesis
    “...–/– mice than in controls. These studies identify the complement system as an important host mediator...”
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  12. 5332
    The NF-κB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation
    “... pulmonary type 2 immune responses. IL-33-mediated activation of ILC2s in vitro as well as in vivo was found...”
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  13. 5333
    Alzheimer’s Disease Microbiome Is Associated with Dysregulation of the Anti-Inflammatory P-Glycoprotein Pathway
    “... intestinal epithelial cell functional assays for P-glycoprotein (P-gp) expression, a critical mediator...”
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  14. 5334
    Manganese Oxide Nanozymes Ameliorate Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve-Transection Induced Neuropathic Pain
    “... as the expression of cyclooxygenase-2 (COX-2), an important mediator of chronic and inflammatory pain in the spinal...”
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  15. 5335
    Chromatin Interaction Responds to Breast Muscle Development and Intramuscular Fat Deposition Between Chinese Indigenous Chicken and Fast-Growing Broiler
    “... in three-dimensional chromatin structure and interaction, a newly emerged mediator of gene expression...”
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  16. 5336
    Long-Term Physical Activity Participation and Subsequent Incident Type 2 Diabetes Mellitus: A Population-Based Cohort Study
    “...-year span and assess association with subsequent 10-year incident DM risk, as well as examine mediation...”
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  17. 5337
    Evaluation of cytokines in peripheral blood mononuclear cell supernatants for the diagnosis of tuberculosis
    “... supernatant (ALS) assay. Here, we aimed to evaluate a panel of inflammatory mediators and associate...”
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  18. 5338
    Do Emotion Dysregulation, Alexithymia and Personality Dimensions Explain the Association Between Attention-Deficit/Hyperactivity Disorder and Binge Eating Among Bariatric Surgery Candidates?
    “..., and to explore the mediational role of emotional factors (emotion dysregulation and alexithymia) and personality...”
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  19. 5339
    Prevention Adaptation of an Evidence-Based Treatment for Parents Involved With Child Welfare Who Use Substances
    “... mediator of successful parent outcomes—engagement.Methods: Graduated FAIR parents (n = 9) and FAIR...”
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  20. 5340
    Correlation of microRNA-16, microRNA-21 and microRNA-101 expression with cyclooxygenase-2 expression and angiogenic factors in cirrhotic and noncirrhotic human hepatocellular carcinoma.
    “...) is a potent mediator of inflammation and is considered to upregulate angiogenesis. The aims...”
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