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  1. 5401
    The unconventional myosin CRINKLED and its mammalian orthologue MYO7A regulate caspases in their signalling roles
    “...In addition to their role in apoptosis, caspases are also involved in mediating non-apoptotic...”
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  2. 5402
    Neonatal genetics of gene expression reveal potential origins of autoimmune and allergic disease risk
    “...Some immune-mediated diseases may originate in early childhood. The authors mapped eQTLs...”
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  3. 5403
    Physical Activity under Stress: A Perspective of HAPA and Individual Differences
    “... students who completed a three-wave survey at six-week intervals. A moderated mediation model was used...”
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  4. 5404
    Conservation of uORF repressiveness and sequence features in mouse, human and zebrafish
    “... and colleagues use bioinformatics approaches to show that conservation of uORF-mediated translational repression...”
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  5. 5405
    The Tec kinase ITK is essential for ILC2 survival and epithelial integrity in the intestine
    “...Signals mediating tissue-specific control of immune cell fate and function remain largely...”
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  6. 5406
    Peptide inhibition of acute lung injury in a novel two-hit rat model.
    “... mediated by an overwhelming innate immunological or inflammatory reaction driven by excessive complement...”
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  7. 5407
    Mechanisms of Siglec-F-induced eosinophil apoptosis: a role for caspases but not for SHP-1, Src kinases, NADPH oxidase or reactive oxygen.
    “... expressed on mouse and human eosinophils, respectively. Whereas Siglec-8 mediated death involves caspases...”
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  8. 5408
    Peptide inhibition of acute lung injury in a novel two-hit rat model
    “... mediated by an overwhelming innate immunological or inflammatory reaction driven by excessive complement...”
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  9. 5409
    CsrA Enhances Cyclic-di-GMP Biosynthesis and <named-content content-type="genus-species">Yersinia pestis</named-content> Biofilm Blockage of the Flea Foregut by Alleviating Hfq-Dependent Repression of the <italic toggle="yes">hmsT</italic> mRNA
    “... biofilm-mediated blockage in the foregut of its flea vector. This biofilm is composed of an extracellular...”
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  10. 5410
    CryoEM structure of the super-constricted two-start dynamin 1 filament
    “...Dynamin mediates the fission of vesicles during endocytosis. Here, the authors report the cryoEM...”
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  11. 5411
    Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch
    “...TRPV1 channels are known to mediate pathological pain and itch. Here, the authors find a naturally...”
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  12. 5412
    PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation
    “...Signalling pathways that mediate macrophage activation in disease are poorly understood. Here...”
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  13. 5413
    Tumor evolution selectively inactivates the core microRNA machinery for immune evasion
    “... show that inactivation of proteins involved in microRNA-mediated gene silencing, such as ANKRD52 or AGO...”
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  14. 5414
    LUBAC prevents lethal dermatitis by inhibiting cell death induced by TNF, TRAIL and CD95L
    “...TNF mediated inflammation is critical in autoimmune mediated pathology, however many patients...”
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  15. 5415
    LPA signaling acts as a cell-extrinsic mechanism to initiate cilia disassembly and promote neurogenesis
    “... that initiates cilia disassembly through both YAP/TAZ mediated transcription and calcium/calmodulin mediated...”
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  16. 5416
    Mechanism of early light signaling by the carboxy-terminal output module of Arabidopsis phytochrome B
    “...Plant phytochromes mediate the degradation of PIF transcription factors to transduce light...”
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  17. 5417
    Phosphorylation of Rab-coupling protein by LMTK3 controls Rab14-dependent EphA2 trafficking to promote cell:cell repulsion
    “...Ephrin receptors mediate contact inhibition, but their intracellular trafficking during...”
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  18. 5418
    Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression
    “.... Here, the authors show that BRAG1 mediates activity-dependent removal of synaptic AMPA receptors via...”
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  19. 5419
    STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer
    “..., the authors show, in breast cancer models, that inflammatory mediators can potentiate complex I inhibitor...”
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  20. 5420
    Vasoactive intestinal peptide controls the suprachiasmatic circadian clock network via ERK1/2 and DUSP4 signalling
    “... to the light-dark cycle. Vasoactive intestinal peptide (VIP) is important for mediating SCN entrainment...”
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