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  1. 6181
    Polycomb dysregulation in gliomagenesis targets a Zfp423-dependent differentiation network
    “...Polycomb-mediated gene regulation has been implicated in gliomas. Here the authors integrate...”
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  2. 6182
    FGF signalling controls the specification of hair placode-derived SOX9 positive progenitors to Merkel cells
    “... and that FGFR2-mediated epithelial signalling is required for their specification....”
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  3. 6183
    In vivo inducible reverse genetics in patients’ tumors to identify individual therapeutic targets
    “..., the authors establish an in vivo inducible RNAi-mediated gene silencing system in patient-derived xenograft...”
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  4. 6184
    A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma
    “... and mediates oncogenic effects through regulation of FOXM1 stability and LIN28B expression....”
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  5. 6185
    Src family kinases activity is required for transmitting purinergic P2X7 receptor signaling in cortical spreading depression and neuroinflammation
    “...Highlights • SFKs activity-mediated P2X7 receptor signaling facilitates CSD propagation via...”
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  6. 6186
    Comprehensive targeting of resistance to inhibition of RTK signaling pathways by using glucocorticoids
    “...TNF signalling was reported to mediate resistance to EGFR inhibition in non-small cell lung cancer...”
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  7. 6187
    Genome wide analysis for mouth ulcers identifies associations at immune regulatory loci
    “... ulcers highlighting genes involved in T cell-mediated immunity and TH1 responses....”
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  8. 6188
    Ionophore constructed from non-covalent assembly of a G-quadruplex and liponucleoside transports K+-ion across biological membranes
    “...DNA based ionophores can mediate efficient ion transport and are crucial to understand...”
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  9. 6189
    MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair
    “... the authors demonstrate how MAD2L2 dimerization mediated through SHLD2 participates in shieldin assembly...”
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  10. 6190
    Direct observation of dual-step twinning nucleation in hexagonal close-packed crystals
    por Yang He, Bin Li, Chongmin Wang, Scott X. Mao
    Publicado 2020
    “... image twinning in rhenium nanocrystals and show the process is mediated by disconnections on Prismatic...”
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  11. 6191
    Large scale meta-analysis characterizes genetic architecture for common psoriasis associated variants
    “...Psoriasis is an immune-mediated skin disease with a complex genetic architecture. Here, Elder...”
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  12. 6192
    Store-independent modulation of Ca2+ entry through Orai by Septin 7
    “...Orai channels are well known to mediate store-operated calcium entry. Here authors show...”
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  13. 6193
    Propagation of temporal and rate signals in cultured multilayer networks
    “... that NMDA-mediated synaptic current generates a sustained phase of activity that propagates firing rate...”
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  14. 6194
    Direct electrochemical oxidation of alcohols with hydrogen evolution in continuous-flow reactor
    “... to the corresponding ketones in a continuous-flow reactor without external oxidants, base or mediators....”
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  15. 6195
    Internalized TSH receptors en route to the TGN induce local Gs-protein signaling and gene transcription
    “... and investigate functional consequences of GPCR-mediated signaling at the Golgi/trans-Golgi network....”
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  16. 6196
    Direction of actin flow dictates integrin LFA-1 orientation during leukocyte migration
    “...Integrin αβ heterodimer cell surface receptors mediate adhesive interactions that provide traction...”
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  17. 6197
    Memory strength gates the involvement of a CREB-dependent cortical fear engram in remote memory
    “... memory. Here, authors demonstrate that memory consolidation by mPFC engram cells requires CREB-mediated...”
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  18. 6198
    Neutrophil-specific deletion of the CARD9 gene expression regulator suppresses autoantibody-induced inflammation in vivo
    “... is involved in the development of sterile auto-antibody-mediated inflammatory reactions....”
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  19. 6199
    Crbn modulates calcium influx by regulating Orai1 during efferocytosis
    “... regulates Orai1 degradation and subsequently SOCE-mediated calcium influx....”
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  20. 6200
    Entanglement of propagating optical modes via a mechanical interface
    “... continuous variable entanglement between two optical modes mediated by a mechanical oscillator....”
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