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  1. 6681
    ARIH1 signaling promotes anti-tumor immunity by targeting PD-L1 for proteasomal degradation
    “... and proteasome mediated degradation by ARIH1 E3 ligase....”
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  2. 6682
    Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease
    “...Mitochondria-lysosome contact sites mediate cross-talk between the two organelles. Here...”
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  3. 6683
    Myomerger promotes fusion pore by elastic coupling between proximal membrane leaflets and hemifusion diaphragm
    “...Myomerger mediates the transition from the early hemifusion stage to complete fusion during...”
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  4. 6684
    SNAREs define targeting specificity of trafficking vesicles by combinatorial interaction with tethering factors
    por Seiichi Koike, Reinhard Jahn
    Publicado 2019
    “...Intracellular vesicle targeting is mediated by Rab GTPases that cooperate...”
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  5. 6685
    Smc5/6 functions with Sgs1-Top3-Rmi1 to complete chromosome replication at natural pause sites
    “... to mediate DNA replication completion at genomic natural pausing sites (NPSs)....”
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  6. 6686
    p53 dynamics vary between tissues and are linked with radiation sensitivity
    “...p53 mediates the response to irradiation, however, tissues with similar levels of p53 have...”
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  7. 6687
    The methyltransferase SETD2 couples transcription and splicing by engaging mRNA processing factors through its SHI domain
    “... methyltransferase SETD2 interacts with hnRNP L to mediate the crosstalk between the transcription and splicing...”
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  8. 6688
    Long non-coding RNA Gm15441 attenuates hepatic inflammasome activation in response to PPARA agonism and fasting
    “...PPAR-alpha is a ligand responsive transcription factor that mediates energy metabolism during...”
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  9. 6689
    Adaptation to chronic drought modifies soil microbial community responses to phytohormones
    “... that drought adaptation within soil microbial communities mediates responses to plant stress signalling....”
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  10. 6690
    KRAS regulation by small non-coding RNAs and SNARE proteins
    “... is mediated by SNARE vesicle transport proteins and that SNORD50A/B compete with these proteins to antagonise...”
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  11. 6691
    T cell costimulation blockade blunts pressure overload-induced heart failure
    “... infiltration of T cells and macrophages, an effect mediated by IL-10, suggesting a potential therapy for heart...”
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  12. 6692
    WUSCHEL acts as an auxin response rheostat to maintain apical stem cells in Arabidopsis
    “... by the WUSCHEL transcription factor maintains stem cells by conferring resistance to auxin mediated...”
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  13. 6693
    Malaria parasites both repress host CXCL10 and use it as a cue for growth acceleration
    “... that are taken up by monocytes resulting in a RIG-I and HUR-1 mediated mechanism of inhibition of CXCL10 protein...”
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  14. 6694
    A BAFF/APRIL axis regulates obesogenic diet-driven weight gain
    “... the role of two structurally and functionally similar immune mediators, BAFF and APRIL, in modifying diet...”
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  15. 6695
    Mammalian body size is determined by interactions between climate, urbanization, and ecological traits
    “... in mediating this dynamic....”
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  16. 6696
    Engineering domain-inlaid SaCas9 adenine base editors with reduced RNA off-targets and increased on-target DNA editing
    “...Off-target effects and the feasibility for AAV-mediated delivery are the major barriers impeding...”
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  17. 6697
    Genome-wide DNA methylation levels and altered cortisol stress reactivity following childhood trauma in humans
    “... ligand gene (KITLG) mediates the relationship between childhood trauma and cortisol stress reactivity....”
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  18. 6698
    ULK1 phosphorylates Exo70 to suppress breast cancer metastasis
    “... mediated phosphorylation of Exo70 leads to opposing effects on tumour cell invasion....”
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  19. 6699
    Topology and structure of an engineered human cohesin complex bound to Pds5B
    “...Cohesin is a ring-shaped protein complex that structures chromatin and mediates sister chromatid...”
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  20. 6700
    TRIM31 promotes Atg5/Atg7-independent autophagy in intestinal cells
    “... of alternative autophagy pathways remain unknown. Here, the authors report that the protein TRIM31 mediates...”
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