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  1. 1221
    Recent advances of cyclin-dependent kinases as potential therapeutic targets in HR+/HER2− metastatic breast cancer: a focus on ribociclib
    por Edessa D, Sisay M
    Publicado 2017
    “... ribociclib found pivotal benefits of ribociclib in HR+/HER2− metastatic breast cancer in terms...”
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  2. 1222
    Altered NCF2, NOX2 mRNA Expression Levels in Peripheral Blood Mononuclear Cells of Pulmonary Tuberculosis Patients
    por Li HM, Huang Q, Tang F, Zhang TP
    Publicado 2021
    “... species (ROS) generated by NADPH oxidase has a pivotal role in the nonspecific innate immune response...”
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  3. 1223
    Genome-Wide Identification and Analysis of NAC Transcription Factor Family in Two Diploid Wild Relatives of Cultivated Sweet Potato Uncovers Potential NAC Genes Related to Drought Tolerance
    “...NAC (NAM, ATAF1/2, and CUC2) proteins play a pivotal role in modulating plant development and offer...”
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  4. 1224
    Twelve-Week Quadriceps Strength as A Predictor of Quadriceps Strength At Time Of Return To Sport Testing Following Bone-Patellar Tendon-Bone Autograft Anterior Cruciate Ligament Reconstruction
    “... = 70.7±16.3 kg). All participants were level 1 or 2 cutting and pivoting sport athletes who underwent a...”
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  5. 1225
    Preferences of Residents in Four Northern Alberta Communities Regarding Local Post-Secondary Programming
    “... and income. Access is the pivotal issue, however: leaving the local community to attend training programs...”
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  6. 1226
    Tinnitus distress is associated with enhanced resting-state functional connectivity within the default mode network
    por Chen YC, Chen H, Bo F, Xu JJ, Deng Y, Lv H, Cai Y, Xia W, Yin X, Gu JP, Lu GM
    Publicado 2018
    “... distress. Increased resting-state connectivity pattern of the DMN may play a pivotal role...”
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  7. 1227
    Mania and bipolar depression: complementing not opposing poles—a post-hoc analysis of mixed features in manic and hypomanic episodes
    “... coefficients and pivotal tables were used to characterize patient groups. Results Mean age of participants...”
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  8. 1228
    Development of molecular markers based on the promoter difference of LcFT1 to discriminate easy- and difficult-flowering litchi germplasm resources and its application in crossbreeding
    “... FLOWERING LOCUS T (FT) homologue gene named LcFT1 played a pivotal role in this process. The present study...”
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  9. 1229
    Grain and bean lysates improve function of endothelial progenitor cells from human peripheral blood: involvement of the endogenous antioxidant defenses.
    “... (EPCs), the pivotal players in the servicing of the endothelial cell lining. Several evidences suggest...”
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  10. 1230
    A Novel Pyroptosis-Related Gene Signature for Prognostic Prediction of Head and Neck Squamous Cell Carcinoma
    por Qian X, Tang J, Chu Y, Chen Z, Chen L, Shen C, Li L
    Publicado 2021
    “... immunity conditions.Conclusion: Pyroptosis-associated genes are pivotal for the prognosis of HNSCC and can...”
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  11. 1231
    Sulfation of Arabinogalactan Proteins Confers Privileged Nutrient Status to <named-content content-type="genus-species">Bacteroides plebeius</named-content>
    “..., which played a pivotal role in the utilization of these glycans by the bacterium. BpS1_8 enabled other...”
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  12. 1232
    The burden of stroke and modifiable risk factors in Ethiopia: A systemic review and meta-analysis
    “... are unclear. Knowledge about this burden and modifying risk factors is pivotal for establishing stroke...”
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  13. 1233
    Assessing the Course of Organ Dysfunction Using Joint Longitudinal and Time-to-Event Modeling in the Vasopressin and Septic Shock Trial
    por Michael O. Harhay, PhD, Alessandro Gasparini, PhD, Allan J. Walkey, MD, MS, Gary E. Weissman, MD, MSHP, Michael J. Crowther, PhD, Sarah J. Ratcliffe, PhD, James A. Russell, MD, on behalf of the Vasopressin and Septic Shock Trial (VASST) Investigators, J. A. Russell, K. R. Walley, C. L. Holmes Boulton, J. T. Granton, P. C. Hebert, D. J. Cooper, S. Mehta, J. Singer, A. C. Gordon, M. M. Storms, S. Jones, J. A. Russell, M. M. Storms, K. R. Walley, G. R. Bernard, A. S. Slutsky, G. A. Wells, A. Gasparini, B. Savage, D. Ayers, R. Woods, K. Wu, M. Maralit, L. Smith, K. Foley, A. Suri, M. Steinberg, B. Howe, P. Galt, A. Higgins, M. M. Storms, M. E. LeBlanc, A. M. Sutherland, A. Sham, A. McLeod, D. R. Dorscheid, M. Hameed, L. Lazosky, S. Helderweirt, C. Honeyman, T. Terins, D. Chittock, J. Ronco, L. Smith, S. Logie, G. Wood, F. Auld, V. Stedham, M. Mantle, L. Fox, G. D. McCauley, J. D. Rolf, C. Erbacher, G. Martinka, S. Goulding, S. Silverwood, L. Leung, S. Keenan, J. Murray, M. Van Osch, B. Light, M. Dominique, P. Gray, R. Stimpson, S. Rosser, D. Bell, W. Janz, P. C. Hebert, T. McArdle, I. Watpool, J. T. Granton, M. Steinberg, A. Matte-Martyn, D. J Cook, E. McDonald, F. Clarke, A. Tkaczyk, N. Zytaruk, T. Stewart, A. Suri, C. Martinez-Motta, R. MacDonald, V. Sivanantham, R. Hodder, J. Foxall, M. Lewis, M. Ward, C. Dos Santos, J. Friedrich, D. Scales, O. Smith, I. DeCampos, A. Richards, H. Michalopoulos, U. Bakshi, W. Sibbald, T. Smith, K. Code, B. Bojilov, C. Dale, M. Keogh, M. Meade, L. Hand, C. Martin, J. Kehoe, V. Binns, M. McGuire, G. Poirier, L. Provost, J. Muscedere, C. Diemer, D. J. Cooper, V. Pellegrino, A. Hilton, S. Morrison, C. Weatherburn, K. Moulden, C. Harry, J. J. Presneill, M. S Robertson, J. F. Cade, B. D. Howe, D. K. Barge, C. A. Boyce, F. Healy, C. Wright, D. Weyandt, J. Barrett, C. Walker, P. Galt, S. Burton, G. Dobb, S. Perryman, J. Chamberlain, L. Thomas, A. Bersten, L. Daly, T. Hunt, D. Wood, B. Patel, J. Larson, M. Rady, G. LeBrun, E. Boyd, R. Rush
    Publicado 2020
    “...) are important clinical endpoints in pivotal sepsis trials. However, comparisons of observed longitudinal non...”
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  14. 1234
    The &beta;3/5 Integrin-MMP9 Axis Regulates Pulmonary Inflammatory Response and Endothelial Leakage in Acute Lung Injury
    “... integrin-MMP-9 axis as an endogenous signal that could play a pivotal role in regulating inflammatory...”
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  15. 1235
    Investigation of Association of Complement 5 Genetic Polymorphisms with Sepsis and Sepsis-Induced Inflammatory Responses
    por Chen K, Lin Y, Liu Y, Liao S, Yang R, Huang J, Xu M, He J
    Publicado 2021
    “...: Complement 5 (C5) and C5a production play a pivotal role in the pathophysiology of sepsis. Strong evidence...”
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  16. 1236
    Age- and Sex-Dependent Patterns of Gut Microbial Diversity in Human Adults
    “... microorganisms may be pivotal in the development of microbial therapies, understanding the factors that shape gut...”
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  17. 1237
    Greater response to placebo in children than in adults: a systematic review and meta-analysis in drug-resistant partial epilepsy.
    “... drug development programs, pivotal trials in children with epilepsy have been completed mostly in Phase...”
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  18. 1238
    Dynamics of the Physicochemical Characteristics, Microbiota, and Metabolic Functions of Soybean Meal and Corn Mixed Substrates during Two-Stage Solid-State Fermentation
    “...) plays pivotal roles not only in human food but also farm animal diets. Soybean meal (SBM) and corn...”
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  19. 1239
    IgE and TGF-&beta; Signaling: From Immune to Cardiac Remodeling
    por Cao H, Xiao C, He Z, Huang H, Tang H
    Publicado 2021
    “... and dysfunction. RNA-seq and downstream analysis indicated that TGF-β was the common pathway and the most pivotal...”
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  20. 1240
    One Year of Coronavirus Disease 2019 (COVID-19) in Brazil: A Political and Social Overview
    “... and sabotaging actions by government had a pivotal role in the country’s current situation. Brazil has a large...”
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